Drug

Probenecid

Established medicine

ClassSolute carrier family 22 member 6 inhibitorResearchOngoing clinical research

Also known as 4-((Dipropylamino)sulfonyl)benzoic acid, 4-(Di-n-propylsulfamoyl)benzoesäure, 4-(N,N-Dipropylsulfamoyl)benzoesäure, Ampicillin-Probenecid+9 more

4-((Dipropylamino)sulfonyl)benzoic acid, 4-(Di-n-propylsulfamoyl)benzoesäure, 4-(N,N-Dipropylsulfamoyl)benzoesäure, Ampicillin-Probenecid, Benemid, Colchicine-Probenecid, Orlynvah, Polycillin-PRB, Probenecid acid, p-(Dipropylsulfamoyl)benzoic acid, Probenecida, Probenecide, Probenecidum.

RxNorm8698 ChEMBLCHEMBL897 ATCM04AB01UNIIPO572Z7917

Active clinical trials

Protein targets

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

An Open-label, Phase 1 Study to Individually Characterize the Food Effect, the Drug-Drug Interaction Effect of OAT Inhibition, and the Drug-Drug Interaction Effect of P-glycoprotein Inhibition on the Pharmacokinetics of MK-8527 in Healthy Adult Participants

Clinical trial2026-09-03Status changed to Active, not recruiting · ClinicalTrials.gov

Novel Use of Probenecid to Alleviate Symptoms of Opioid Withdrawal in People With Chronic Pain Undergoing Voluntary Opioid Tapering: a Pilot Study

Clinical trial2026-05-01Results expected Q4 2026 · ClinicalTrials.gov

Probenecid, Pannexin 1 Channels for Alcohol Use Disorder

Clinical trial2026-03-17Results expected Q4 2030 · ClinicalTrials.gov

Efficacy of Probenecid on Cluster Seizures During Anti Seizure Medication Withdrawal in Presurgical Focal Epilepsy Video-EEG Monitoring

Clinical trial2026-01-06Results expected Q1 2029 · ClinicalTrials.gov

Treatment of Veterans With Heart Failure With Reduced Ejection Fraction With Probenecid

Clinical trial2025-12-31Completed · ClinicalTrials.gov

AN INTERVENTIONAL, PHASE 1, OPEN-LABEL, TWO-COHORT, TWO-PERIOD, FIXED SEQUENCE STUDY TO ESTIMATE THE EFFECT OF MULTIPLE DOSES OF ITRACONAZOLE AND PROBENECID ON THE PHARMACOKINETICS OF SINGLE DOSE PF-07220060 ADMINISTERED UNDER THE FED CONDITION TO HEALTHY PARTICIPANTS

Clinical trial2025-12-22Completed · ClinicalTrials.gov

Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters

Clinical trial2025-08-08Results posted · ClinicalTrials.gov

Addition of Probenecid to Penicillin-V Therapy: an Open Label, Cross-over Study in Healthy Volunteers

Clinical trial2025-01-30Results posted · ClinicalTrials.gov

An Open-Label Study to Assess the Effect of Povorcitinib on Digoxin, Rosuvastatin, and Metformin Pharmacokinetics and the Effect of Probenecid on Povorcitinib Pharmacokinetics When Administered Orally to Healthy Adult Participants

Clinical trial2025-01-15Completed · ClinicalTrials.gov

Relative Bioavailability of Two Different BI 690517 Formulations as Well as the Effect of Multiple Doses of Probenecid on the Single Dose Pharmacokinetics of BI 690517 Following Oral Administration in Healthy Male and Female Subjects (a Randomised, Open-label, Three-way Crossover Trial)

Clinical trial2025-01-07Completed · ClinicalTrials.gov

A Single Dose Oral Bioavailability Study of PanCytoVir™ Oral Suspension (100 mg/ml) 1000 mg Versus Probenecid 500 mg Tablets, 1000 mg (2 X 500 mg) in Healthy, Adult, Human Subjects Under Fasting Conditions

Clinical trial2024-10-15Completed · ClinicalTrials.gov

A Open-Label, Two-sequence Phase I Drug-drug Interaction Clinical Study to Investigate the Pharmacokinetics of ZSP1273 With Digoxin, Rosuvastatin,Itraconazole and Probenecid in Healthy Participants

Clinical trial2023-11-30Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Probenecid

Aliases & brands

4-((Dipropylamino)sulfonyl)benzoic acid4-(Di-n-propylsulfamoyl)benzoesäure4-(N,N-Dipropylsulfamoyl)benzoesäureAmpicillin-ProbenecidBenemidColchicine-ProbenecidOrlynvahPolycillin-PRBProbenecid acidp-(Dipropylsulfamoyl)benzoic acidProbenecidaProbenecideProbenecidum

RxNorm CUI

8698

ChEMBL ID

CHEMBL897

ATC codes

M04AB01

UNII

PO572Z7917

Primary mechanism

Solute carrier family 22 member 6 inhibitor