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Drug

Propofol

Approved · FDA
Emerging researchLate-stage developmentSteady momentum
Also known as Diprivan, Propovan, Propoven, Propoflo+3 more

Diprivan, Propovan, Propoven, Propoflo, 2,6-Diisopropylphenol, 2,6-bis(1-methylethyl)phenol, Propofolum.

RxNorm8782ChEMBLCHEMBL526UNIIYI7VU623SF
4
Research papers
17
Active clinical trials
1
Regulatory events
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

COMPARISON OF PROPOFOL INFUSION VS INHALATIONAL AGENT ISOFLURANE IN TERMS OF CONTROLLED HYPOTENSION IN PATIENTS UNDERGOING ENDOSCOPIC SINUS SURGERY

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

Effects of Remimazolam and Ciprofol Total Intravenous Anesthesia on Perioperative Respiratory Adverse Events in Pediatric Tonsillectomy and Adenoidectomy: A Randomized Controlled Study

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

Approval: PROPOFOL (ANDA220857)

Regulatory2026-07-14FDA

Effect of Propofol, Midazolam, and Dexmedetomidine on Intracranial Pressure and Clinical Outcomes in Patients With Moderate-to-Severe Traumatic Brain Injury Undergoing Urgent Neurosurgical Intervention

Clinical trial2026-07-01Results expected Q2 2028 · ClinicalTrials.gov

Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration (SERENE)

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia

Clinical trial2026-06-26Results expected Q1 2027 · ClinicalTrials.gov

Remimazolam With Planned Flumazenil Reversal Versus Sevoflurane-based Balanced Anesthesia for Hysteroscopic Day Surgery: A Randomized Controlled Trial

Clinical trial2026-06-23Results expected Q2 2028 · ClinicalTrials.gov

Flex Appeal: A Prospective Randomized Controlled Trial Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia (MUA)

Clinical trial2026-06-03Results expected Q3 2027 · ClinicalTrials.gov

Comparison of different anesthesia techniques during esophagogastroduedenoscopy in children: a randomized trial.

Research2015-07-17Paediatric anaesthesia

Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines.

Research2013-04-01Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

Propofol interruption of ECT seizure to reduce side-effects: a pilot study.

Research2009-11-05Psychiatry research

Use of an EEG-bispectral closed-loop delivery system for administering propofol.

Research2000-09-01Acta anaesthesiologica Scandinavica

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Propofol
Aliases & brands
DiprivanPropovanPropovenPropoflo2,6-Diisopropylphenol2,6-bis(1-methylethyl)phenolPropofolum
RxNorm CUI
8782
ChEMBL ID
CHEMBL526
UNII
YI7VU623SF
Regulatory jurisdictions
fda

Regulatory timeline

1 event

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval
2026-07-14
Latest approval
2026-07-14
Authorities
FDA
Total events
1
fdaU.S. Food and Drug Administration· 1 event
2026-07-14Approval
Approval: PROPOFOL (ANDA220857)
Evidence ↗

Data from the U.S. Food and Drug Administration (U.S. Food and Drug Administration), public domain (CC0).

Clinical trials

189 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
189
registered trials across all phases
LATEST COMPLETION 2026
17
Active studies
14
Recruiting
162
Late-stage (III+)
107
Completed
65
Discontinued
PHASE DISTRIBUTIONn = 189
Early Phase 14Phase 17Phase 1 / 23Phase 213Phase 2 / 31Phase 320Phase 457Phase N / A84

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Patients Undergoing Moderate- to High-risk Major Noncardiac Surgery - a Prospective, Observer-blinded, Randomized, Clinical Trial

RecruitingPH IVKey trialMedical University of Viennan=1,3322028

Remimazolam With Planned Flumazenil Reversal Versus Sevoflurane-based Balanced Anesthesia for Hysteroscopic Day Surgery: A Randomized Controlled Trial

Not yet recruitingPH IVChung-Ang University Gwangmyeong Hospitaln=1242028

Flex Appeal: A Prospective Randomized Controlled Trial Evaluating the Efficacy of Anesthetic Techniques for Manipulation of Knees Under Anesthesia (MUA)

RecruitingPH IVDuke Universityn=1282027

Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia

Not yet recruitingPH IVGeneral Hospital of Ningxia Medical Universityn=1082027

Optimizing Anesthesia to Prevent Postoperative Cognitive and Functional Decline in Older Adults: A Randomized Controlled Trial

RecruitingPH IVOregon Health and Science Universityn=2602027

Recent completions

Trials that read out recently, adding to the completed evidence base.

Comparison of Propofol and Remifentanil for Sedation in Elective Gastroscopy: A Prospective Randomized Study Evaluating Safety, Recovery Quality, and Endoscopist Satisfaction

CompletedN/AFatih Sultan Mehmet Training and Research Hospitaln=802026

The Effects of Induction Agents Applied During Electroconvulsive Therapy on Seizure Duration, Seizure Quality, and Recovery Time

CompletedN/ADr. Lutfi Kirdar Kartal Training and Research Hospitaln=1002025

A Randomized Controlled Trial Comparing Propofol and Ketofol for Hemodynamic Stability During Electroconvulsive Therapy

CompletedN/AFauji Foundation Hospitaln=802025

Ciprofol Versus Propofol for Tracheal Intubation in ICU Patients: a Randomized Controlled Pilot Study

CompletedPH IVShanghai Zhongshan Hospitaln=1002025

Sedation With Dexmedetomidine or Midazolam in Combination With Propofol for Removal of Double-J Ureteral Stent: A Randomized Double-Blinded Study

CompletedN/ATanta Universityn=602025

Comparison of the Efficacy of Intravenous Propofol-Ketamine and Sevoflurane Administered Via Face Mask in Children Undergoing Magnetic Resonance Imaging: A Prospective, Randomized, Parallel-Group Study

CompletedN/AKocaeli City Hospitaln=2302025

Research activity

4 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20002015
Most influential

Use of an EEG-bispectral closed-loop delivery system for administering propofol.

Acta anaesthesiologica Scandinavica · 2000 · 16 cites

Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2013 · 15 cites

Comparison of different anesthesia techniques during esophagogastroduedenoscopy in children: a randomized trial.

Paediatric anaesthesia · 2015 · 6 cites

Propofol interruption of ECT seizure to reduce side-effects: a pilot study.

Psychiatry research · 2010 · 3 cites
Major research themes6
Anesthesia, Intravenous1Anesthetics, Intravenous1Duodenoscopy1Electroencephalography1Esophagoscopy1Propofol1
Journals, researchers & institutions
Top journals
  • Academic emergency medicine : official journal of the Society for Academic Emergency Medicine1
  • Acta anaesthesiologica Scandinavica1
  • Paediatric anaesthesia1
  • Psychiatry research1
Leading researchers
  • Giesecke AH1
  • Glynn S1
  • Gray RO1
  • Gunter J1
  • Ho JD1
  • Hoffmann C1
  • Hossain MM1
  • Kibelbek MJ1
Leading institutions
free-text, unnormalised
  • Cincinnati Children's Hospital Medical Center1
  • Cincinnati Children's Medical Center1
  • Hennepin County Medical Center1
  • Loma Linda University1
  • University of Hirosaki School of Medicine1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials
  • Regulatory event sources are credited in the Regulatory Timeline above.