Drug

Propranolol

Approved · EMA

Emerging researchLate-stage developmentCooling momentum

Also known as 1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol, 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol, Hemangeol, Inderal+9 more

1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol, 1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol, Hemangeol, Inderal, Inderide, InnoPran, Hydrochlorothiazide-Propranolol, beta-Propranolol, Propanalol, Propanolol, Propranololo, Propranolol Hydrochloride, Propranololum.

RxNorm8787 ChEMBLCHEMBL27 ATCC07AA05UNII9Y8NXQ24VQ

Research papers

Active clinical trials

Regulatory events

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Neoadjuvant Iparomlimab/Tuvonralimab Plus CAPEOX Versus Iparomlimab/Tuvonralimab Plus CAPEOX and Propranolol for Locally Advanced pMMR Colon Cancer: A Prospective, Single-Center, Multi-Cohort Study

Clinical trial2026-07-31Primary completion · ClinicalTrials.gov

Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

Mismatch vs. Standard Intervention During Memory Reconsolidation Blockade With Propranolol: Effect on Psychophysiological Reactivity During Traumatic Imagery

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

Perioperative Stress Reduction in Ovarian Cancer (PRESERVE Trial)-A Prospective Randomized Pilot Study

Clinical trial2026-07-01Results expected Q2 2027 · ClinicalTrials.gov

Chemotherapy Combined With Propranolol Hydrochloride as Neoadjuvant Therapy for Advanced High-grade Serous Ovarian Cancer: A Prospective, Multicenter, Phase II Clinical Study

Clinical trial2026-06-30Results expected Q3 2026 · ClinicalTrials.gov

Efficacy and Safety of Different Initial Doses of Oral Propranolol in the Treatment of Ulcerated Infantile Hemangioma： a Prospective Study

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The APT Comparison Study

Clinical trial2026-06-29Results expected Q1 2029 · ClinicalTrials.gov

Effects of a True Prophylactic Treatment on Hippocampal and Amygdala Synaptic Plasticity and Gene Expression in a Rodent Chronic Stress Model of Social Defeat.

Research2023-07-07International journal of molecular sciences

Propranolol inhibits molecular risk markers in HCT recipients: a phase 2 randomized controlled biomarker trial.

Research2020-02-01Blood advances

A randomized, controlled trial of oral propranolol in infantile hemangioma.

Research2015-02-01The New England journal of medicine

Pharmacological blockade of memory reconsolidation in posttraumatic stress disorder: three negative psychophysiological studies.

Research2014-09-16Psychiatry research

Approval: Hemangiol (EMA)

Regulatory2014-04-23EMA

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Propranolol

Aliases & brands

1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol1-(isopropylamino)-3-(1-naphthyloxy)propan-2-olHemangeolInderalInderideInnoPranHydrochlorothiazide-Propranololbeta-PropranololPropanalolPropanololPropranololoPropranolol HydrochloridePropranololum

RxNorm CUI

8787

ChEMBL ID

CHEMBL27

ATC codes

C07AA05

UNII

9Y8NXQ24VQ

Regulatory jurisdictions

ema

Regulatory timeline

1 event

The complete regulatory record, grouped by authority — approvals, safety advisories and label changes. Each authority shows its most recent events; expand one to read its full history.

Earliest approval

2014-04-23

Latest approval

2014-04-23

Authorities

EMA

Total events

emaEuropean Medicines Agency· 1 event

2014-04-23Approval

Approval: Hemangiol (EMA)

Indication: Hemangiol is indicated in the treatment of proliferating infantile haemangioma requiring systemic therapy: Life- or function-threatening haemangioma, Ulcerated haemangioma with… Show full indication

Hemangiol is indicated in the treatment of proliferating infantile haemangioma requiring systemic therapy: Life- or function-threatening haemangioma, Ulcerated haemangioma with pain and/or lack of response to simple wound care measures, Haemangioma with a risk of permanent scars or disfigurement. It is to be initiated in infants aged 5 weeks to 5 months.

Evidence ↗

Contains information from the European Medicines Agency (European Medicines Agency), © EMA, reused under CC BY 4.0.

Clinical trials

198 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

198

registered trials across all phases

LATEST COMPLETION 2025

Active studies

Recruiting

102

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 198

Early Phase 112Phase 123Phase 1 / 26Phase 255Phase 2 / 313Phase 316Phase 441Phase N / A32

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

A Pragmatic Clinical Trial to Evaluate the Impact of Clinical Propranolol Strategies on Myocardial Injury After Non-cardiac Surgery (MINS) in Patients Undergoing Breast Cancer Surgery With Hypertension or Angina

Not yet recruitingPH IVChang-Ik Yoonn=1002033

Comparative Outcomes of Migraine Preventives and Anti-CGRP Therapies for Tinnitus in Patients With Migraine: A Randomized Active-Comparator Controlled Trial (COMPACT-PM)

Not yet recruitingPH IVStanford Universityn=1202031

A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The APT Comparison Study

RecruitingPH IVKey trialMayo Clinicn=1,3352029

Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences

RecruitingPH IVUniversity of Albertan=302027

Comparative Efficacy of Propranolol, Flunarizine, and Their Combination in Migraine Prophylaxis: An Open-label Parallel-arm Randomized Controlled Trial

Not yet recruitingPH IVChittagong Medical Collegen=1772027

Recent completions

Trials that read out recently, adding to the completed evidence base.

Adrenergic Contribution to Glucose Counterregulation in Islet Transplantation

CompletedPH IUniversity of Pennsylvanian=92025

Effectivity and Safety of GB20 Acupoint Pharmacopuncture With Lidocaine 2% on Migraine Patients : Study on Head Pain Characteristic and MIDAS-Ina Score

CompletedN/AIndonesia Universityn=302025

A Phase 2, Randomized, Open-Label Study to Assess the Safety and Efficacy of GPC 100 and Propranolol With and Without G-CSF for the Mobilization of Stem Cells in Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

CompletedPH IIGPCR Therapeutics, Inc.n=302025

Reconsolidation Therapy With Propranolol as a Novel Treatment for Chronic Pain : a Placebo-controlled Feasibility Study

CompletedPH IIUniversité de Sherbrooken=482025

Testing a Novel Therapeutic Strategy for Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder

CompletedPH IICentre for Addiction and Mental Healthn=482025

Efficacy and Safety of Propranolol for the Post-Stroke Pneumonia

CompletedPH II/IIIBeijing Tiantan Hospitaln=1682025

Research activity

6 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20122023

Most influential

A randomized, controlled trial of oral propranolol in infantile hemangioma.

The New England journal of medicine · 2015 · 510 cites

Pharmacological blockade of memory reconsolidation in posttraumatic stress disorder: three negative psychophysiological studies.

Psychiatry research · 2015 · 131 cites

Effect of acute posttrauma propranolol on PTSD outcome and physiological responses during script-driven imagery.

CNS neuroscience & therapeutics · 2012 · 99 cites

Propranolol inhibits molecular risk markers in HCT recipients: a phase 2 randomized controlled biomarker trial.

Blood advances · 2020 · 42 cites

Modulation of remifentanil-induced postinfusion hyperalgesia by the β-blocker propranolol in humans.

Pain · 2012 · 41 cites

Effects of a True Prophylactic Treatment on Hippocampal and Amygdala Synaptic Plasticity and Gene Expression in a Rodent Chronic Stress Model of Social Defeat.

International journal of molecular sciences · 2023 · 13 cites

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Mifepristone

Frequently co-studied with Propranolol in the research literature.

2 shared papers

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials
Regulatory event sources are credited in the Regulatory Timeline above.