Drug

Quetiapine

In clinical development

Emerging researchLate-stage development

Also known as Seroquel, Quetiapina, QUEtiapine Fumarate, Quetiapinum.

RxNorm51272 ChEMBLCHEMBL716UNIIBGL0JSY5SI

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

A Pragmatic Randomized Trial Comparing Antipsychotics in Lewy Body Disease

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

The Efficacy and Mechanism of Different Intervention Strategy for Bipolar II Disorder Patients With Rhythm Disturbance

Clinical trial2026-06-17Results expected Q3 2029 · ClinicalTrials.gov

Effectiveness of Switching Antipsychotic Medications

Clinical trial2026-05-15Results posted · ClinicalTrials.gov

Mirtazapine and Quetiapine as Treatment for Postoperative Sleep Disturbance After Fast-track Knee Replacement

Clinical trial2026-05-01Primary completion · ClinicalTrials.gov

A Randomised, Controlled Trial to Investigate the Effect of an Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

Clinical trial2026-01-22Results expected Q2 2028 · ClinicalTrials.gov

Sequential Multiple Assignment Randomized Trial for Bipolar Depression

Clinical trial2025-12-16Results expected Q1 2030 · ClinicalTrials.gov

A Randomised, Controlled Trial to Investigate the Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

Clinical trial2025-09-26Results expected Q2 2028 · ClinicalTrials.gov

A Pilot, Double-blind, Randomized Trial of Quetiapine Versus Trazadone in Women With Postpartum Depression

Clinical trial2025-09-01Primary completion · ClinicalTrials.gov

CSP #2015 - Multicenter, Randomized, Double-blind Comparator Study of Antipsychotics Pimavanserin and Quetiapine for Parkinson''s Disease Psychosis (C-SAPP)

Clinical trial2025-08-28Results expected Q4 2026 · ClinicalTrials.gov

Quetiapine for Bipolar Disorder and Alcohol Dependence

Clinical trial2025-07-25Results posted · ClinicalTrials.gov

A human laboratory study investigating the effects of quetiapine on marijuana withdrawal and relapse in daily marijuana smokers.

Research2012-06-28Addiction biology

Double-blind placebo-controlled trial of quetiapine in anorexia nervosa.

Research2012-04-26European eating disorders review : the journal of the Eating Disorders Association

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Quetiapine

Aliases & brands

SeroquelQuetiapinaQUEtiapine FumarateQuetiapinum

RxNorm CUI

51272

ChEMBL ID

CHEMBL716

UNII

BGL0JSY5SI

Clinical trials

155 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

155

registered trials across all phases

LATEST COMPLETION 2024

Active studies

Recruiting

128

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 155

Early Phase 12Phase 18Phase 1 / 22Phase 215Phase 2 / 36Phase 333Phase 471Phase N / A18

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Comparison of Trazodone vs Quetiapine vs Placebo for the Treatment of ICU Delirium: A Randomized Controlled Trial (The TraQ Study)

WithdrawnPH IVUniversity of Southern California2030

Sequential Multiple Assignment Randomized Trial for Bipolar Depression

Active, not recruitingPH IVKey trialMassachusetts General Hospitaln=2,7262030

CSP #2015 - Multicenter, Randomized, Double-blind Comparator Study of Antipsychotics Pimavanserin and Quetiapine for Parkinson''s Disease Psychosis (C-SAPP)

RecruitingPH IVVA Office of Research and Developmentn=3582027

A Pragmatic Randomized Trial Comparing Antipsychotics in Lewy Body Disease

RecruitingPH IVThe University of Texas Health Science Center at San Antonion=942027

Comparative Efficacy of Antidepressant Augmentation With Amantadine vs Pramipexole vs Quetiapine in Treatment-resistant Unipolar Depression: A Randomized Controlled Trial.

Unknown statusPH IVAll India Institute of Medical Sciences, Bhubaneswarn=1502024

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Phase II, 6-week, Multicenter, Randomized, Double-blind, Double-dummy, Placebo-controlled, Parallel Group Trial With a Quetiapine Arm to Evaluate the Efficacy, Tolerability and Safety of Oral BI 1358894 in Patients With Major Depressive Disorder With Inadequate Response to Antidepressants.

CompletedPH IIBoehringer Ingelheimn=3892024

Role of Quetiapine in the Prevention of ICU Delirium in Elderly Patients at a High Risk

CompletedPH IIAin Shams Universityn=902023

Effects of Quetiapine on Sleep and Next Day Alertness in People With Obstructive Sleep Apnea

CompletedPH IIFlinders Universityn=152023

Synergistic Effect of Vitamin E & D in Reducing the Risk of Effects Associated With Atypical Antipsychotics

CompletedN/ADr Rabia Arshadn=1402021

A Randomized Controlled Trial of Quetiapine for the Treatment of Youth With Co-occurring Substance Use Disorders and Severe Mood Dysregulation

CompletedPH IVBoston Medical Centern=242021

A Prospective, Matched-Control, Randomized, Open-Label, Flexible-Dose, Study in Subjects With Recent-Onset Schizophrenia or Schizophreniform Disorder to Compare Disease Progression and Disease Modification Following Treatment With Paliperidone Palmitate Long-Acting Injection or Oral Antipsychotics

CompletedPH IIIJanssen Scientific Affairs, LLCn=3372019

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time

20122013

Most influential

A human laboratory study investigating the effects of quetiapine on marijuana withdrawal and relapse in daily marijuana smokers.

Addiction biology · 2013 · 43 cites

Double-blind placebo-controlled trial of quetiapine in anorexia nervosa.

European eating disorders review : the journal of the Eating Disorders Association · 2012 · 29 cites