Drug

Sertraline

In clinical development

Emerging researchLate-stage developmentRising momentum

Also known as (1S,4S)-sertraline, Zoloft, cis-(+)-sertraline, (+)-Sertraline+4 more

(1S,4S)-sertraline, Zoloft, cis-(+)-sertraline, (+)-Sertraline, Sertralina, (1S-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine, Sertraline Hydrochloride, Sertralinum.

RxNorm36437 ChEMBLCHEMBL809 ATCN06AB06UNIIQUC7NX6WMB

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Neural Markers of Treatment Mechanisms and Prediction of Treatment Outcomes in Social Anxiety

Clinical trial2026-07-23Results expected Q2 2027 · ClinicalTrials.gov

Efficacy and Safety of Ammoxetine Hydrochloride Enteric-coated Tablets in Subjects With Depression: A Multicenter, Randomized, Double-blind, Double-Dummy, Placebo-controlled and Sertraline Active-controlled, Parallel-group, Phase III Study

Clinical trial2026-06-30Primary completion · ClinicalTrials.gov

A Study on the Efficacy and Safety of Sertraline Combined With Multi-Strain Probiotics in Treating Adolescent Patients With Depression: A Multi-Center Randomized Controlled Clinical Trial

Clinical trial2026-06-12Results expected Q4 2028 · ClinicalTrials.gov

Allopurinol Adjuvant Therapy in Patients With Major Depressive Disorder

Clinical trial2026-05-07Results expected Q2 2027 · ClinicalTrials.gov

Accelerating Cognition-guided Signatures to Enhance Translation in Depression Aim 3: Clinical Cognitive Trial

Clinical trial2026-03-05Results expected Q4 2028 · ClinicalTrials.gov

Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD): a Pragmatic Clinical Trial

Clinical trial2026-01-27Results expected Q4 2026 · ClinicalTrials.gov

A Randomised, Controlled Trial to Investigate the Effect of an Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

Clinical trial2026-01-22Results expected Q2 2028 · ClinicalTrials.gov

Treatment of Orthostatic Intolerance

Clinical trial2025-10-08Results expected Q4 2029 · ClinicalTrials.gov

Sertraline modulates hippocampal plasticity via sigma 1 receptors, cellular stress and neurosteroids.

Research2024-11-21Translational psychiatry

Luteal phase sertraline treatment of premenstrual dysphoric disorder (PMDD): Effects on markers of hypothalamic pituitary adrenal (HPA) axis activation and inflammation.

Research2024-07-24Psychoneuroendocrinology

GABAergic neuroactive steroid response to sertraline in premenstrual dysphoric disorder.

Research2023-11-30Psychoneuroendocrinology

Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice.

Research2023-06-30Microbiome

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Sertraline

Aliases & brands

(1S,4S)-sertralineZoloftcis-(+)-sertraline(+)-SertralineSertralina(1S-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamineSertraline HydrochlorideSertralinum

RxNorm CUI

36437

ChEMBL ID

CHEMBL809

ATC codes

N06AB06

UNII

QUC7NX6WMB