Drug

Sevoflurane

In clinical development

ClassGABA-A receptor; anion channel positive allosteric modulatorEmerging researchLate-stage development

Also known as Petrem, SevoFlo, Sevospire, Sojourn+7 more

Petrem, SevoFlo, Sevospire, Sojourn, Ultane, Sevofluran, Sevoflurano, Sévoflurane, 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane, Fluoromethyl 2,2,2-trifluoro-1-(trifluromethyl)ethyl ether, Sevofluranum.

RxNorm36453 ChEMBLCHEMBL1200694 ATCN01AB08UNII38LVP0K73A

Research papers

Active clinical trials

Protein targets

Latest activity

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Recent clinical, regulatory, research and industry developments relating to this drug.

The Effect of Low-Flow Sevoflurane and Low-Flow Desflurane Anesthesia on Postoperative Sore Throat in Laparoscopic Cholecystectomy Surgery

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

To Compare the Effects of Intraoperative Use of Intravenous Anesthetics Propofol and Inhaled Anesthetics Sevoflurane on the Prognosis of Patients Undergoing Surgery for Primary Brain, Liver, Lung, and Ovarian Cancer Tumors and the Investigation of Its Mechanism of Action

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

Remimazolam With Planned Flumazenil Reversal Versus Sevoflurane-based Balanced Anesthesia for Hysteroscopic Day Surgery: A Randomized Controlled Trial

Clinical trial2026-06-23Results expected Q2 2028 · ClinicalTrials.gov

Comparison of the Immunomodulatory Effects of Sevoflurane and Propofol Anesthesia on Pentraxin-3 and Serum Amyloid A Levels in Obese Patients Undergoing Lumbar Instrumentation Surgery

Clinical trial2026-06-15Primary completion · ClinicalTrials.gov

Response Surface Model Between Remimazolam and Sevoflurane; Comparison of the Minto and the Greco Model

Clinical trial2026-06-02Results expected Q2 2027 · ClinicalTrials.gov

Comparison of the Effects of Sevoflurane and Desflurane Used for Anesthesia Maintenance on Optic Nerve Sheath Diameter in the Trendelenburg Position

Clinical trial2026-06-01Completed · ClinicalTrials.gov

Effect of Sevoflurane on Sweat Threshold in Children of Different Ages

Clinical trial2026-05-01Primary completion · ClinicalTrials.gov

Neurodevelopmental Outcome After Standard Dose Sevoflurane Versus Low-dose Sevoflurane/Dexmedetomidine/Remifentanil Anaesthesia in Young Children- The TREX Trial

Clinical trial2026-03-01Primary completion · ClinicalTrials.gov

Dynamic Effects of Different Anesthetic Agents on the Immune Function of Healthy Volunteers

Clinical trial2026-02-04Results expected Q3 2026 · ClinicalTrials.gov

Sevoflurane's Effect on Neurocognition Study

Clinical trial2026-01-30Completed · ClinicalTrials.gov

Cerebral Hemodynamic and Metabolic Responses to Anesthesia and Vasopressors in Adult Surgery: A 2x2 Factorial Design Randomized Controlled Trial With Light-based Neuromonitoring (CHEM-FACT Study)

Clinical trial2025-12-31Primary completion · ClinicalTrials.gov

Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments.

Research2025-02-08Journal of advanced research

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Sevoflurane

Aliases & brands

PetremSevoFloSevospireSojournUltaneSevofluranSevofluranoSévoflurane1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propaneFluoromethyl 2,2,2-trifluoro-1-(trifluromethyl)ethyl etherSevofluranum

RxNorm CUI

36453

ChEMBL ID

CHEMBL1200694

ATC codes

N01AB08

UNII

38LVP0K73A

Primary mechanism

GABA-A receptor; anion channel positive allosteric modulator

Pharmacology & targets

23 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

Gamma-aminobutyric acid receptor subunit alpha-1

GABRA1 · P14867