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Drug

Silver Nitrate

In clinical development
Emerging researchLate-stage development
Also known as Avoca, Nitrate d'argent, Nitrato de plata, Silver Nitrate Ophthalmic+4 more

Avoca, Nitrate d'argent, Nitrato de plata, Silver Nitrate Ophthalmic, Silver mononitrate, Silver nitrate (in water), Styptstix, silver(1+) nitrate.

RxNorm9789ChEMBLCHEMBL177367ATCD08AL01UNII95IT3W8JZE
1
Research papers
2
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Efficacy and Safety of 0.5% w/v Nano- Silver Nitrate Versus Silver Nitrate Solution for Bronchoscopic Lung Volume Reduction in Management of Localized Emphysema: Prospective Interventional Randomized Controlled Clinical Trial

Clinical trial2025-12-01Primary completion · ClinicalTrials.gov

A Comparative Study of Silver Nitrate, Triamcinolone, and Their Successive Combined Use on Hypergranulation Tissue in Traumatic Wounds: A Randomized Control Trial

Clinical trial2025-03-10Results expected Q4 2028 · ClinicalTrials.gov

Topical 15% Trichloroacetic Acid Versus Silver Nitrate Cauterization in the Management of Idiopathic Childhood Epistaxis: A Prospective Double-Blinded, Randomized Clinical Trial

Clinical trial2024-11-02Completed · ClinicalTrials.gov

Comparison of Phenol and Silver Nitrate Application in the Sacrococcygeal Pilonidal Sinus: A Prospective Randomized Controlled Study

Clinical trial2023-06-15Completed · ClinicalTrials.gov

Outcome Of Treatment With Silver Nitrate Versus Topical Steroid For Umbilical Granuloma In Terms Of Healing After 3 Weeks Of Treatment

Clinical trial2023-05-01Completed · ClinicalTrials.gov

Treatment of Tracheostomy Granulomas

Clinical trial2021-09-13Results posted · ClinicalTrials.gov

Management Of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis

Clinical trial2019-12-01Primary completion · ClinicalTrials.gov

Synthesis and biological characterization of silver nanoparticles derived from the cyanobacterium Oscillatoria limnetica.

Research2019-09-10Scientific reports

Granulation Tissue at G Tube Site: Treatment With Kenalog vs Chemical Cauterization With Silver Nitrate vs Soap Washcloth Abrasion

Clinical trial2018-11-13Terminated · ClinicalTrials.gov

Medical Management of Caries in the Primary Dentition Using Silver Nitrate: A Pilot Study

Clinical trial2018-08-21Completed · ClinicalTrials.gov

A Prospective, Randomised Controlled Trial to Determine the Safety and Efficacy of Steroid Impregnated Tape Compared to Standard Therapy With Silver Nitrate in the Treatment of Over-granulating Peritoneal Dialysis Catheter Exit Sites

Clinical trial2017-03-01Completed · ClinicalTrials.gov

Randomized Clinical Trial Comparing Silver Nitrate Application With Topical Corticosteroids for Hypergranulation Tissue at Gastrostomy Sites

Clinical trial2015-12-01Primary completion · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Silver Nitrate
Aliases & brands
AvocaNitrate d'argentNitrato de plataSilver Nitrate OphthalmicSilver mononitrateSilver nitrate (in water)Styptstixsilver(1+) nitrate
RxNorm CUI
9789
ChEMBL ID
CHEMBL177367
ATC codes
D08AL01
UNII
95IT3W8JZE

Clinical trials

13 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
13
registered trials across all phases
LATEST COMPLETION 2024
2
Active studies
2
Recruiting
8
Late-stage (III+)
7
Completed
4
Discontinued
PHASE DISTRIBUTIONn = 13
Early Phase 11Phase 1 / 21Phase 23Phase 2 / 31Phase 32Phase 43Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Comparison of Phenol and Silver Nitrate Application in the Sacrococcygeal Pilonidal Sinus: A Prospective Randomized Controlled Study

CompletedPH IVUmraniye Education and Research Hospitaln=442023

Treatment of Tracheostomy Granulomas

CompletedPH IVUniversity of Colorado, Denvern=262019

Randomized Clinical Trial Comparing Silver Nitrate Application With Topical Corticosteroids for Hypergranulation Tissue at Gastrostomy Sites

Unknown statusPH IVAkron Children's Hospitaln=502016

A Comparative Study of Silver Nitrate, Triamcinolone, and Their Successive Combined Use on Hypergranulation Tissue in Traumatic Wounds: A Randomized Control Trial

Not yet recruitingPH II/IIIFrancesco Egron=2702028

Granulation Tissue at G Tube Site: Treatment With Kenalog vs Chemical Cauterization With Silver Nitrate vs Soap Washcloth Abrasion

TerminatedPH IIIUniversity of Michigann=522018

Recent completions

Trials that read out recently, adding to the completed evidence base.

Topical 15% Trichloroacetic Acid Versus Silver Nitrate Cauterization in the Management of Idiopathic Childhood Epistaxis: A Prospective Double-Blinded, Randomized Clinical Trial

CompletedN/AYoussef Zakin=1702024

Comparison of Phenol and Silver Nitrate Application in the Sacrococcygeal Pilonidal Sinus: A Prospective Randomized Controlled Study

CompletedPH IVUmraniye Education and Research Hospitaln=442023

Outcome Of Treatment With Silver Nitrate Versus Topical Steroid For Umbilical Granuloma In Terms Of Healing After 3 Weeks Of Treatment

CompletedPH IIChildren Hospital and Institute of Child Health, Lahoren=3542023

Treatment of Tracheostomy Granulomas

CompletedPH IVUniversity of Colorado, Denvern=262019

Medical Management of Caries in the Primary Dentition Using Silver Nitrate: A Pilot Study

CompletedPH IArwa Owaisn=1222018

A Prospective, Randomised Controlled Trial to Determine the Safety and Efficacy of Steroid Impregnated Tape Compared to Standard Therapy With Silver Nitrate in the Treatment of Over-granulating Peritoneal Dialysis Catheter Exit Sites

CompletedPH IIIUniversity Hospital Birmingham NHS Foundation Trustn=322017

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes1
Metal Nanoparticles1
Journals, researchers & institutions
Top journals
  • Scientific reports1
Leading researchers
  • Abo-Elmagd RA1
  • Bawazir SS1
  • Hamouda RA1
  • Hussein MH1
Leading institutions
free-text, unnormalised
  • Genetic Engineering & Research Institute1
  • Mansoura University1
  • University of Jeddah1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Silver

Studied across the same disease area as Silver Nitrate in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials