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Drug

Solifenacin

In clinical development
Emerging researchLate-stage development

Also known as VESIcare, Solifenacina, Solifenacin Succinate.

RxNorm322167ChEMBLCHEMBL1734UNIIA8910SQJ1U
2
Research papers
11
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Efficacy of Solifenacin, Mirabegron and Combination Therapy in Children With Overactive Bladder and Daytime Urinary Incontinence (BeDry)

Clinical trial2026-06-08Results expected Q4 2027 · ClinicalTrials.gov

Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry)

Clinical trial2026-06-08Results expected Q4 2027 · ClinicalTrials.gov

Melatonin Versus Solifenacin Versus Their Combination for Improving Double-J Ureteral Stent-Related Symptoms and Quality of Life: A Prospective Randomized Study

Clinical trial2026-06-02Results expected Q2 2027 · ClinicalTrials.gov

Efficacy, Neural Repair Mechanism, and Health Economics of a Multimodal Treat-to-Target Strategy Incorporating Vitamin D for Pediatric Overactive Bladder-Wet: A Randomized Controlled Trial

Clinical trial2026-04-17Results expected Q3 2026 · ClinicalTrials.gov

Low-intensity Shockwave Therapy Versus Solifenacin for the Treatment of Overactive Bladder in Women: A Randomized Controlled Trial

Clinical trial2026-03-16Results expected Q2 2027 · ClinicalTrials.gov

A Phase II Randomized Study of Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer Patients Receiving Adjuvant Hormonal Therapy

Clinical trial2026-03-05Results expected Q3 2027 · ClinicalTrials.gov

Efficacy and Tolerability of Solifenacin Combined With Gabapentin Versus Solifenacin Monotherapy for the Treatment of Non-neurogenic Overactive Bladder in Women: A Randomized Controlled Trial

Clinical trial2026-02-24Results expected Q4 2026 · ClinicalTrials.gov

Randomized Controlled Trial Comparing Low Dose Tadalafil Versus Solifenacin For Management of Overactive Bladder in Women: Multicenter Egyptian National Study (WoMEN'S)

Clinical trial2026-02-18Results expected Q3 2026 · ClinicalTrials.gov

A Comparative Study on the Efficacy of Tamsulosin, Solifenacin and Mirabegron in Alleviating Ureteral Stent-related Symptoms: a Randomized Controlled Trial

Clinical trial2025-12-01Primary completion · ClinicalTrials.gov

Efficacy of Combination of Solifenacin and Tadalafil Versus Solifenacin Alone in Treatment of Overactive Bladder in Females

Clinical trial2025-11-15Completed · ClinicalTrials.gov

Solifenacin plus tamsulosin combination treatment in men with lower urinary tract symptoms and bladder outlet obstruction: a randomized controlled trial.

Research2012-07-17European urology

Effects of solifenacin on overactive bladder symptoms, symptom bother and other patient-reported outcomes: results from VIBRANT - a double-blind, placebo-controlled trial.

Research2009-12-01International journal of clinical practice

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Solifenacin
Aliases & brands
VESIcareSolifenacinaSolifenacin Succinate
RxNorm CUI
322167
ChEMBL ID
CHEMBL1734
UNII
A8910SQJ1U

Clinical trials

105 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
105
registered trials across all phases
LATEST COMPLETION 2025
11
Active studies
10
Recruiting
84
Late-stage (III+)
73
Completed
21
Discontinued
PHASE DISTRIBUTIONn = 105
Phase 110Phase 1 / 22Phase 29Phase 2 / 31Phase 323Phase 443Phase N / A17

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Strategy for Withdrawal of Pharmacological Treatment for Urinary Incontinence in Children (StayDry)

Active, not recruitingPH IVUniversity of Aarhusn=2162027

Low-intensity Shockwave Therapy Versus Solifenacin for the Treatment of Overactive Bladder in Women: A Randomized Controlled Trial

RecruitingPH IVMansoura Universityn=702027

Randomized Controlled Trial Comparing Low Dose Tadalafil Versus Solifenacin For Management of Overactive Bladder in Women: Multicenter Egyptian National Study (WoMEN'S)

RecruitingPH IVMansoura Universityn=4802026

Comparative Efficacy of Tamsulosin and Solifenacin in Managing Double J Stent-Related Symptoms: A Randomized Clinical Study Using the USSQ Tool.

CompletedPH IVLiaquat National Hospital & Medical Collegen=602025

Efficacy of Tadalafil and Solifenacin Versus Tamsulosin and Solifenacin Combination Therapy for the Treatment of Benign Prostatic Hyperplasia With Overactive Bladder: A Randomized Controlled Trial

Unknown statusPH IVMansoura Universityn=602022

Recent completions

Trials that read out recently, adding to the completed evidence base.

Efficacy of Combination of Solifenacin and Tadalafil Versus Solifenacin Alone in Treatment of Overactive Bladder in Females

CompletedN/AAin Shams Universityn=802025

Efficacy and Mechanism of High-Dose Vitamin D Supplementation in Pediatric OAB-Dry: A Randomized Clinical Trial Integrating Urinary Myelin Basic Protein as a Theranostic Biomarker

CompletedN/AXing Liun=1802025

Comparative Efficacy of Tamsulosin and Solifenacin in Managing Double J Stent-Related Symptoms: A Randomized Clinical Study Using the USSQ Tool.

CompletedPH IVLiaquat National Hospital & Medical Collegen=602025

A Multicenter, Double-blind, Placebo-controlled and Active-reference, Randomized, Parallel, Therapeutic Confirmatory Clinical Study to Evaluate the Efficacy and Safety of DA-8010 in Patients With Overactive Bladder

CompletedPH IIIDong-A ST Co., Ltd.n=6072024

Behavioral or Solifenacin Therapy for Urinary Symptoms in Parkinson Disease

CompletedPH IIIVA Office of Research and Developmentn=772023

Efficacy and Safety of High Dose Vitamin D Supplementation for Overactive Bladder Dry in Children: A Randomized Clinical Trial

CompletedN/AXing Liun=3032023

Research activity

2 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20092013
Journals, researchers & institutions
Top journals
  • European urology1
  • International journal of clinical practice1
Leading researchers
  • He W2
  • Cummings J1
  • Fakhoury A1
  • Forero-Schwanhaeuser S1
  • Kaplan SA1
  • Koltun WD1
  • Marshall TS1
  • Mitcheson HD1
Leading institutions
free-text, unnormalised
  • Mount Sinai School of Medicine1
  • Weill Medical College of Cornell University1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials