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Drug

Sorbitol

In clinical development
Emerging researchLate-stage development
Also known as Activated Charcoal with Sorbitol, Arlex, D-(-)-sorbitol, D-Sorbit+6 more

Activated Charcoal with Sorbitol, Arlex, D-(-)-sorbitol, D-Sorbit, D-Sorbitol, D-glucitol, G-ol, L-Gulitol, Mannitol-Sorbitol, (-)-sorbitol.

RxNorm9945ChEMBLCHEMBL1682ATCV04CC01ATCB05CX02ATCA06AD18ATCA06AG07UNII506T60A25R
1
Research papers
1
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Safety and Efficacy Study of Oral Sorbitol to Enhance the Therapeutic Effect of Neoadjuvant Chemotherapy Combined With Tirellizumab (PD-1 Inhibitor) in Patients With Locally Advanced Gastric Cancer

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

An Open-label Study to Evaluate the Effect of Activated Charcoal With Sorbitol on the Pharmacokinetics of Mavacamten in Healthy Participants

Clinical trial2022-09-11Completed · ClinicalTrials.gov

A Phase 2, Randomised, Placebo Controlled Study to Evaluate the Efficacy, Tolerability and Safety of Metabolic Cofactor Supplementation in Obese Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD)

Clinical trial2022-05-06Completed · ClinicalTrials.gov

A Phase 2, Randomized, Placebo Controlled Study to Evaluate the Efficacy, Tolerability and Safety of Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) And Parkinson's Disease (PD) Patients

Clinical trial2021-04-20Completed · ClinicalTrials.gov

Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications.

Research2020-10-12Journal of diabetes research

An Open-label Single-Center, 4-Period William's Cross-Over Design Drug Interaction Trial to Determine the Effects of Sorbitol-Containing Solutions on Lamivudine Exposure Following Administration of Lamivudine Oral Solution in Healthy Adult Subjects

Clinical trial2017-05-15Results posted · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Sorbitol
Aliases & brands
Activated Charcoal with SorbitolArlexD-(-)-sorbitolD-SorbitD-SorbitolD-glucitolG-olL-GulitolMannitol-Sorbitol(-)-sorbitol
RxNorm CUI
9945
ChEMBL ID
CHEMBL1682
ATC codes
V04CC01B05CX02A06AD18A06AG07
UNII
506T60A25R

Clinical trials

5 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
5
registered trials across all phases
LATEST COMPLETION 2022
1
Active studies
1
Recruiting
2
Late-stage (III+)
4
Completed
PHASE DISTRIBUTIONn = 5
Phase 11Phase 22Phase 2 / 31Phase 41

Recent completions

Trials that read out recently, adding to the completed evidence base.

An Open-label Study to Evaluate the Effect of Activated Charcoal With Sorbitol on the Pharmacokinetics of Mavacamten in Healthy Participants

CompletedPH IBristol-Myers Squibbn=452022

A Phase 2, Randomised, Placebo Controlled Study to Evaluate the Efficacy, Tolerability and Safety of Metabolic Cofactor Supplementation in Obese Subjects With Non-Alcoholic Fatty Liver Disease (NAFLD)

CompletedPH IIScandiBio Therapeutics ABn=322022

A Phase 2, Randomized, Placebo Controlled Study to Evaluate the Efficacy, Tolerability and Safety of Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) And Parkinson's Disease (PD) Patients

CompletedPH IIIstanbul Medipol University Hospitaln=1202021

An Open-label Single-Center, 4-Period William's Cross-Over Design Drug Interaction Trial to Determine the Effects of Sorbitol-Containing Solutions on Lamivudine Exposure Following Administration of Lamivudine Oral Solution in Healthy Adult Subjects

CompletedPH IVViiV Healthcaren=162016

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes2
Glycemic Index1Oxidative Stress1
Journals, researchers & institutions
Top journals
  • Journal of diabetes research1
Leading researchers
  • Lambadiari V1
  • Makrilakis K1
  • Maratou E1
  • Papachristoforou E1
Leading institutions
free-text, unnormalised
  • National and Kapodistrian University of Athens Medical School1
  • Research Unit and Diabetes Centre1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials