Drug

Sulfasalazine

Established medicine

ClassCyclooxygenase inhibitorResearchOngoing clinical research

Also known as 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid, 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene, 5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid, 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid+13 more

2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid, 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene, 5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid, 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid, 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid, Azulfidine, Azulfidine EN-tabs, Salazosulfapiridina, Salazosulfapyridine, Salazosulfapyridinum, Salicylazosulfapyridine, Sulfazine, 柳氮磺吡啶, Sulfasalazin, Sulfasalazina, Sulphasalazine, Sulfasalazinum.

RxNorm9524 ChEMBLCHEMBL421 ATCA07EC01UNII3XC8GUZ6CB

Active clinical trials

Protein targets

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Immunosuppressant Management in Rheumatology Patients Undergoing Elective Total Shoulder Arthroplasty

Clinical trial2026-07-09Results expected Q1 2028 · ClinicalTrials.gov

The Effect of Sulfasalazine on CRH Levels in Pregnant Women With a History of Pre-Term Birth: A Randomized Controlled Trial

Clinical trial2026-07-09Results expected Q1 2028 · ClinicalTrials.gov

Treatment of Rheumatoid Arthritis With Disease-modifying Antirheumatic Drugs (DMARDs): Predictors of Response

Clinical trial2026-06-17Results expected Q1 2028 · ClinicalTrials.gov

A Phase Ib/II Randomized, Open Label Drug Repurposing Trial of Glutamate Signaling Inhibitors in Combination With Chemoradiotherapy in Patients With Newly Diagnosed Glioblastoma

Clinical trial2026-06-01Primary completion · ClinicalTrials.gov

A Randomized, Placebo-controlled Pilot Study of Sulfasalazine for the Treatment of Primary Sclerosing Cholangitis (PSC)

Clinical trial2026-03-03Completed · ClinicalTrials.gov

Clinical Effectiveness of Standard Step up Care (Methotrexate) Compared to Early Combination DMARD Therapy With Standard Step up Care Compared to Early Use of TNF Inhibitors With Standard Step up Care for the Treatment of Moderate to Severe Psoriatic Arthritis: a 3-arm Parallel Group Randomised Controlled Trial.

Clinical trial2025-11-26Results posted · ClinicalTrials.gov

Phase I/II Clinical Trial Assessing the Combination of Sulfasalazine With Standard of Care Induction Therapy in Newly Diagnosed Acute Myeloid Leukemias (AML) Patients 60 Years or Older- the SALMA Study

Clinical trial2025-11-01Primary completion · ClinicalTrials.gov

Clinical Study Evaluating the Efficacy and Safety of Sulfasalazine in Patients With Metastatic Colorectal Cancer

Clinical trial2025-09-30Primary completion · ClinicalTrials.gov

A Prospective, Single Arm, Open Label, Proof of Concept Clinical Study of Sulfasalazine in the Treatment of Active Systemic Lupus Erythematosus

Clinical trial2025-05-01Primary completion · ClinicalTrials.gov

Double Blind Trial Investigating the Role of Sulfasalazine in Decreasing Opioids Requirements in Breast Cancer Patients

Clinical trial2025-01-09Results posted · ClinicalTrials.gov

A Prospective, Randomized, Controlled, Open Label, Assessor-blinded, Parallel-group Phase III Clinical Trial to Evaluate the Impact of Tapering Systemic Immunosuppressive Therapy in a Treat-to-target Approach on Maintaining Minimal Disease Activity in Adult Subjects With Psoriatic Arthritis

Clinical trial2024-10-19Primary completion · ClinicalTrials.gov

Adjunctive Effect of Topical Sulfasalazine for Oral Lichen Planus Management: A Randomized Clinical Trial

Clinical trial2024-09-01Primary completion · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Sulfasalazine

Aliases & brands

2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acidAzulfidineAzulfidine EN-tabsSalazosulfapiridinaSalazosulfapyridineSalazosulfapyridinumSalicylazosulfapyridineSulfazine柳氮磺吡啶SulfasalazinSulfasalazinaSulphasalazineSulfasalazinum

RxNorm CUI

9524

ChEMBL ID

CHEMBL421

ATC codes

A07EC01

UNII

3XC8GUZ6CB

Primary mechanism

Cyclooxygenase inhibitor