Drug

Tetradecanoylphorbol Acetate

In clinical development

Emerging researchEarly-to-mid development

Also known as Pma (phorbol ester), Tpa (phorbol ester), 12-o-tetradecanoylphorbol-13-acetate, 12-tetradecanoylphorbol 13-acetate+3 more

Pma (phorbol ester), Tpa (phorbol ester), 12-o-tetradecanoylphorbol-13-acetate, 12-tetradecanoylphorbol 13-acetate, Phorbol 12-myristate 13-acetate, Phorbol 12-myristate 13-acetate diester, Phorbol myristate acetate.

RxNorm10398 ChEMBLCHEMBL279115UNIINI40JAQ945

Research papers

Latest activity

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Recent clinical, regulatory, research and industry developments relating to this drug.

A Phase II Study of 12-O-tetradecanoylphorbol-13-acetate (TPA) Plus Dexamethasone & Choline Magnesium Trisalicylate in the Treatment of Patients With Relapsed/Refractory Acute Myelogenous Leukemia

Clinical trial2014-09-01Terminated · ClinicalTrials.gov

The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.

Research2010-01-13PloS one

Phase I Study of 12-O-tetradecanoylphorbol-13-acetate (TPA) in Patients With Refractory Hematologic Malignancies/Bone Marrow Disorders

Clinical trial2004-11-01Terminated · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Tetradecanoylphorbol Acetate

Aliases & brands

Pma (phorbol ester)Tpa (phorbol ester)12-o-tetradecanoylphorbol-13-acetate12-tetradecanoylphorbol 13-acetatePhorbol 12-myristate 13-acetatePhorbol 12-myristate 13-acetate diesterPhorbol myristate acetate

RxNorm CUI

10398

ChEMBL ID

CHEMBL279115

UNII

NI40JAQ945

Clinical trials

2 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

Discontinued

PHASE DISTRIBUTIONn = 2

Phase 11Phase 21

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

The identification of markers of macrophage differentiation in PMA-stimulated THP-1 cells and monocyte-derived macrophages.

PloS one · 2010 · 896 cites

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Nitric Oxide

Frequently co-studied with Tetradecanoylphorbol Acetate in the research literature.

1 shared paper

References & data sources

RxNorm (U.S. National Library of Medicine) — drug identity
ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
Europe PMC — research literature
ClinicalTrials.gov — clinical trials