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Drug

Thioctic Acid

In clinical development
Emerging researchLate-stage developmentRising momentum
Also known as (+)-alpha-Lipoic acid, (R)-(+)-Lipoate, .ALPHA.-LIPOIC ACID, ALPHA LIPOIC ACID+14 more

(+)-alpha-Lipoic acid, (R)-(+)-Lipoate, .ALPHA.-LIPOIC ACID, ALPHA LIPOIC ACID, ALPHA-LIPOIC ACID, Alphalipoic acid, D-thioctic acid, Lipoic Acid, Q-Gel with Lipoic Acid, R-(+)-thioctic acid, R-alpha-lipoic acid, Thioctic acid D-form, alpha-Liponsäure, (R)-1,2-Dithiolane-3-pentanoic acid, (R)-1,2-dithiolane-3-valeric acid, (R)-6,8-thioctic acid, .ALPHA.-LIPOIC ACID, (+/-)-, 1,2-dithiolane-3-pentanoic acid.

RxNorm6417ChEMBLCHEMBL33864ATCA16AX01UNII73Y7P0K73Y
3
Research papers
10
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Phase II Trial of the Combination of Alpha-lipoic Acid and Mirabegron in Women and in Men With Obesity

Clinical trial2026-07-10Results expected Q1 2030 · ClinicalTrials.gov

Evaluation of the Effect of Different Treatments on Pain Scores and Self-reported Oral Health-related Quality of Life in Individuals With Burning Mouth Syndrome: a Randomized Controlled Clinical Trial

Clinical trial2026-07-01Primary completion · ClinicalTrials.gov

A Randomized Controlled Trial Evaluating the Efficacy of Alpha Lipoic Acid Combined With Myo-Inositol With or Without Metformin in Non-Diabetic Women With Polycystic Ovary Syndrome

Clinical trial2026-06-05Results expected Q3 2026 · ClinicalTrials.gov

Effect of Low-Dose Versus High-Dose Alpha-Lipoic Acid on Oxidative Stress, Inflammation, and Clinical Outcomes in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Clinical trial2026-05-28Primary completion · ClinicalTrials.gov

The Effect of Alpha Lipoic Acid on the Clinical Outcome of Advanced Non-Small Cell Lung Cancer Patients

Clinical trial2026-05-08Results expected Q1 2027 · ClinicalTrials.gov

Evaluation of Alpha-Lipoic Acid in Mitigating Cisplatin-Induced Nephrotoxicity in Oncology Patients

Clinical trial2026-05-04Results expected Q1 2027 · ClinicalTrials.gov

Impact of Adding Quercetin or Alpha Lipoic Acid as an Adjuvant Therapy on Clinical and Biochemical Outcomes in a Sample of Iraqi PCOS Patients

Clinical trial2026-05-01Primary completion · ClinicalTrials.gov

The Effect of Lipoic Acid Natural Supplement on Cystine Stone Formation

Clinical trial2026-04-15Results posted · ClinicalTrials.gov

Effect of Alpha Lipoic Acid on the Clinical Outcome of Pediatric Patients Undergoing Hemodialysis

Clinical trial2026-03-02Results expected Q4 2027 · ClinicalTrials.gov

Alpha lipoic acid administration improved both peripheral sensitivity to insulin and liver clearance of insulin reducing potential risk of diabetes and nonalcoholic fatty liver disease in overweight/obese PCOS patients.

Research2024-04-15Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Metabolic and clinical effect of alpha-lipoic acid administration in schizophrenic subjects stabilized with atypical antipsychotics: A 12-week, open-label, uncontrolled study.

Research2022-06-28Current research in pharmacology and drug discovery

Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial.

Research2011-07-20Diabetes care

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Thioctic Acid
Aliases & brands
(+)-alpha-Lipoic acid(R)-(+)-Lipoate.ALPHA.-LIPOIC ACIDALPHA LIPOIC ACIDALPHA-LIPOIC ACIDAlphalipoic acidD-thioctic acidLipoic AcidQ-Gel with Lipoic AcidR-(+)-thioctic acidR-alpha-lipoic acidThioctic acid D-formalpha-Liponsäure(R)-1,2-Dithiolane-3-pentanoic acid(R)-1,2-dithiolane-3-valeric acid(R)-6,8-thioctic acid.ALPHA.-LIPOIC ACID, (+/-)-1,2-dithiolane-3-pentanoic acid
RxNorm CUI
6417
ChEMBL ID
CHEMBL33864
ATC codes
A16AX01
UNII
73Y7P0K73Y

Clinical trials

78 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
78
registered trials across all phases
LATEST COMPLETION 2025
10
Active studies
8
Recruiting
47
Late-stage (III+)
48
Completed
20
Discontinued
PHASE DISTRIBUTIONn = 78
Early Phase 12Phase 14Phase 1 / 25Phase 220Phase 2 / 37Phase 313Phase 418Phase N / A9

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Evaluation of the Effect of Different Treatments on Pain Scores and Self-reported Oral Health-related Quality of Life in Individuals With Burning Mouth Syndrome: a Randomized Controlled Clinical Trial

Active, not recruitingPH IVFederal University of Minas Geraisn=1502026

Effect of Alpha Lipoic Acid on Chemotherapy Induced Neurological Changes in Breast Cancer Patients

Unknown statusPH IVAin Shams Universityn=922025

Clinical Study of Lipoic Acid on Ischemic Heart Failure

CompletedPH IVShanghai Zhongshan Hospitaln=3002025

A Multicenter, Interventional, Two-arm, Parallel-group, Randomized, Double-blinded, Placebo-controlled, Phase IV Trial to Evaluate the Efficacy of Alpha-Lipoic Acid in the Treatment of Symptomatic Diabetic Polyneuropathy in Egypt

CompletedPH IVEva Pharman=4302024

Effect of Alpha-Lipoic Acid Supplementation on the Incidence of Postoperative Atrial Fibrillation in Cardiac Surgery Patients

Unknown statusPH IVAin Shams Universityn=3502024

Recent completions

Trials that read out recently, adding to the completed evidence base.

Evaluation of the Impact of Alpha Lipoic Acid Administration on the Prevention of Doxorubicin-induced Cardiotoxicity in Breast Cancer Patients

CompletedPH IIBritish University In Egyptn=802025

Clinical Study of Lipoic Acid on Ischemic Heart Failure

CompletedPH IVShanghai Zhongshan Hospitaln=3002025

The Effect of Lipoic Acid Natural Supplement on Cystine Stone Formation

CompletedPH IIThomas Chi, MDn=502024

A Multicenter, Interventional, Two-arm, Parallel-group, Randomized, Double-blinded, Placebo-controlled, Phase IV Trial to Evaluate the Efficacy of Alpha-Lipoic Acid in the Treatment of Symptomatic Diabetic Polyneuropathy in Egypt

CompletedPH IVEva Pharman=4302024

Lipoic Acid for the Treatment of Progressive Multiple Sclerosis

CompletedPH IIVA Office of Research and Developmentn=1152024

Assessment of Resveratrol, Alpha Lipoic Acid and Superoxide Dismutase on Oxidative Stress Biomarkers in Type 2 Diabetes Mellitus Patients With Neuropathy: A Randomized Control Trial

CompletedPH IIKhyber Medical University Peshawarn=1002024

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20112024
Major research themes5
Diabetes Mellitus1Insulin Resistance1Non-alcoholic Fatty Liver Disease1Polycystic Ovary Syndrome1Thioctic Acid1
Journals, researchers & institutions
Top journals
  • Current research in pharmacology and drug discovery1
  • Diabetes care1
  • Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology1
Leading researchers
  • Aio C1
  • Basile GA1
  • Battipaglia C1
  • Boulton AJ1
  • Bruno A1
  • Campolo D1
  • Di Benedetto A1
  • Dyck PJ1
Leading institutions
free-text, unnormalised
  • Gynecological Endocrinology Center1
  • Institute for Clinical Diabetology1
  • Polyclinic Hospital University of Messina1
  • University of Messina1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Insulin

Studied across 6 of the same disease areas as Thioctic Acid in the shared literature.

6 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials