Drug

Tianeptine

In clinical development

Emerging researchLate-stage development

Also known as Tianeptina.

RxNorm38252 ChEMBLCHEMBL1289110 ATCN06AX14UNII0T493YFU8O

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Evaluation of the Efficacy of Perioperative Administration of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. A Double-Blinded Randomized Controlled Trial.

Clinical trial2025-03-01Completed · ClinicalTrials.gov

Classics in Chemical Neuroscience: Tianeptine.

Research2024-10-09ACS chemical neuroscience

Randomized, Double-blind, Placebo-controlled Trial of the Efficacy and Safety of Tianeptine in the Treatment of Covid Fog Symptoms in Patients After COVID-19 With the Study of the Pathophysiology of the Phenomenon Using Positron Emission Tomography, Biochemical, Immunological and Electrophysiological Parameters.

Clinical trial2023-08-25Results expected Q2 2027 · ClinicalTrials.gov

Can Brain Activation and Connectivity Predict Treatment Response to Two Serotonergic Medications (Citalopram and Tianeptine) in Subjects With Autism Spectrum Disorders (ASD)?

Clinical trial2023-02-01Primary completion · ClinicalTrials.gov

Double Blind,Randomized, Placebo Controlled Trial of Adjunctive Tianeptine in the Treatment of Bipolar Depression

Clinical trial2013-05-01Primary completion · ClinicalTrials.gov

Comparison of Tianeptine Versus Escitalopram for the Treatment of Depression and Cognitive Impairment in Patients With Major Depressive Disorder: A Randomized, Multicenter, Open-label Study

Clinical trial2012-09-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Tianeptine

Aliases & brands

Tianeptina

RxNorm CUI

38252

ChEMBL ID

CHEMBL1289110

ATC codes

N06AX14

UNII

0T493YFU8O

Clinical trials

5 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2025

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 5

Phase 21Phase 31Phase 41Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Comparison of Tianeptine Versus Escitalopram for the Treatment of Depression and Cognitive Impairment in Patients With Major Depressive Disorder: A Randomized, Multicenter, Open-label Study

CompletedPH IVSamsung Medical Centern=1642012

Double Blind,Randomized, Placebo Controlled Trial of Adjunctive Tianeptine in the Treatment of Bipolar Depression

Unknown statusPH IIIHospital de Clinicas de Porto Alegren=132013

Recent completions

Trials that read out recently, adding to the completed evidence base.

CompletedN/ANational Cancer Institute, Egyptn=902025

Comparison of Tianeptine Versus Escitalopram for the Treatment of Depression and Cognitive Impairment in Patients With Major Depressive Disorder: A Randomized, Multicenter, Open-label Study

CompletedPH IVSamsung Medical Centern=1642012

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Classics in Chemical Neuroscience: Tianeptine.

ACS chemical neuroscience · 2024 · 7 cites