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Drug

Tirofiban

In clinical development
Emerging researchLate-stage development

Also known as Aggrastat, N-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosine, Tirofibán, Tirofibanum.

RxNorm73137ChEMBLCHEMBL916ATCB01AC17UNIIGGX234SI5H
1
Research papers
11
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Efficacy and Safety of Tirofiban Therapy in Acute Ischemic Stroke Patients Beyond the Time Window Guided by High-Resolution Magnetic Resonance Imaging

Clinical trial2026-06-25Results expected Q1 2029 · ClinicalTrials.gov

Effects of Intracoronary Recombinant Human TNK Tissue-type Plasminogen Activator Versus Tirofiban on Myocardial Perfusion and Clinical Prognosis in Patients With ST-segment Elevation Myocardial Infarction and High Thrombus Burden: a Multicenter, Randomized, Controlled, Single-blind, Non-inferior Study

Clinical trial2026-05-22Results expected Q4 2027 · ClinicalTrials.gov

Efficacy and Safety of Immediate Intra-Arterial Tirofiban After Mechanical Thrombectomy Recanalization in Acute Intracranial Large-Vessel Occlusion

Clinical trial2026-04-22Results expected Q2 2028 · ClinicalTrials.gov

Induced Suppression of Platelet Activity in Aneurysmal Subarachnoid Hemorrhage Management-2

Clinical trial2026-03-25Results expected Q1 2029 · ClinicalTrials.gov

Randomized Multi-center Clinical Trial to Assess Effectiveness and Safety of Tirofiban Versus Intravenous Aspirin in Patients With Acute Ischemic Stroke Secondary to Tandem Injury, Subject to Recanalization Therapy Through Endovascular Treatment

Clinical trial2026-03-20Completed · ClinicalTrials.gov

Intravenous Adjuvant With Tirofiban Versus Alteplase Before Mechanical Thrombectomy in Acute Ischemic Stroke Patients With Large Vessel Occlusion: a Multicenter, Open Label, Randomized Controlled Trial.

Clinical trial2026-02-28Primary completion · ClinicalTrials.gov

Efficacy and Safety of Tirofiban in Patients With Acute Branch Atheromatous Disease (BAD)- Related Stroke (BRANT)

Clinical trial2026-02-26Completed · ClinicalTrials.gov

Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic Stroke: A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial

Clinical trial2026-01-30Primary completion · ClinicalTrials.gov

Intravenous Tirofiban After Bridging Therapy for Acute Stroke With Atherosclerotic Large Artery Occlusion (RESCUE-AS): A Multicenter, Randomized, Open Label, Blinded Endpoint Study

Clinical trial2026-01-13Results expected Q1 2027 · ClinicalTrials.gov

Safety and Efficacy of Adjunct Tirofiban Treatment After Successful Mechanical Thrombectomy Recanalization in Acute Anterior Circulation Ischemic Stroke- A Multicenter, Prospective, Double-blind, Randomized Trial

Clinical trial2025-12-29Completed · ClinicalTrials.gov

Intravenous Thrombolysis Combined With Tirofiban in Acute Ischemic Stroke: A Multicenter, Prospective, Double-Blind, Placebo-Controlled, Randomized Controlled Trial

Clinical trial2025-12-23Results expected Q4 2026 · ClinicalTrials.gov

Comparison of early invasive and conservative strategies in patients with unstable coronary syndromes treated with the glycoprotein IIb/IIIa inhibitor tirofiban.

Research2001-06-01The New England journal of medicine

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Tirofiban
Aliases & brands
AggrastatN-(Butylsulfonyl)-O-(4-(4-piperidyl)butyl)-L-tyrosineTirofibánTirofibanum
RxNorm CUI
73137
ChEMBL ID
CHEMBL916
ATC codes
B01AC17
UNII
GGX234SI5H

Clinical trials

38 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
38
registered trials across all phases
LATEST COMPLETION 2026
11
Active studies
11
Recruiting
35
Late-stage (III+)
17
Completed
10
Discontinued
PHASE DISTRIBUTIONn = 38
Phase 11Phase 1 / 21Phase 21Phase 2 / 34Phase 310Phase 419Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Effects of Intracoronary Recombinant Human TNK Tissue-type Plasminogen Activator Versus Tirofiban on Myocardial Perfusion and Clinical Prognosis in Patients With ST-segment Elevation Myocardial Infarction and High Thrombus Burden: a Multicenter, Randomized, Controlled, Single-blind, Non-inferior Study

RecruitingPH IVHenan Institute of Cardiovascular Epidemiologyn=3002027

Intravenous Thrombolysis Combined With Tirofiban in Acute Ischemic Stroke: A Multicenter, Prospective, Double-Blind, Placebo-Controlled, Randomized Controlled Trial

RecruitingPH IVBeijing Anzhen Hospitaln=9762026

Randomized Multi-center Clinical Trial to Assess Effectiveness and Safety of Tirofiban Versus Intravenous Aspirin in Patients With Acute Ischemic Stroke Secondary to Tandem Injury, Subject to Recanalization Therapy Through Endovascular Treatment

CompletedPH IVFundación Pública Andaluza para la gestión de la Investigación en Sevillan=2402026

Reduction of Microembolism After Stent-Assisted Coil Embolization of Unruptured Intracranial Aneurysms by Administration of Tirofiban：A Randomized, Controlled, Double-blind Trial

Unknown statusPH IVLu Huan=702023

Early Initiation of Low Dose Tirofiban for Primary Percutaneous Coronary Intervention in Patients With ST-segment Elevation Myocardial Infarction.

Unknown statusPH IVShanghai Zhongshan Hospitaln=5002021

Recent completions

Trials that read out recently, adding to the completed evidence base.

Randomized Multi-center Clinical Trial to Assess Effectiveness and Safety of Tirofiban Versus Intravenous Aspirin in Patients With Acute Ischemic Stroke Secondary to Tandem Injury, Subject to Recanalization Therapy Through Endovascular Treatment

CompletedPH IVFundación Pública Andaluza para la gestión de la Investigación en Sevillan=2402026

Efficacy and Safety of Tirofiban in Patients With Acute Branch Atheromatous Disease (BAD)- Related Stroke (BRANT)

CompletedPH IIIPeking Union Medical College Hospitaln=5162026

Safety and Efficacy of Adjunct Tirofiban Treatment After Successful Mechanical Thrombectomy Recanalization in Acute Anterior Circulation Ischemic Stroke- A Multicenter, Prospective, Double-blind, Randomized Trial

CompletedPH II/IIIKey trialXiang Luon=1,3802025

Prophylactic Administration of Tirofiban for Preventing Thromboembolic Events in Stent-assisted Coiling and Flow Diversion Treatments of Unruptured Intracranial Aneurysms

CompletedPH II/IIIBeijing Tiantan Hospitaln=1922025

Platelet Inhibition With GP IIb/IIIa Inhibitor in Critically Ill Patients With Coronavirus Disease 2019 (COVID-19). A Compassionate Use Protocol

CompletedPH IIUniversity of Milann=52020

Facilitation Through Aggrastat or Cangrelor Bolus and Infusion Over prasugreL: a mUlticenter Randomized Open-label Trial in patientS With ST-elevation Myocardial inFarction Referred for primAry percutaneouS inTERvention.FABOLUS FASTER Trial

CompletedPH IVInsel Gruppe AG, University Hospital Bernn=1222019

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes1
Angioplasty, Balloon, Coronary1
Journals, researchers & institutions
Top journals
  • The New England journal of medicine1
Leading researchers
  • Braunwald E1
  • Cannon CP1
  • DeLucca PT1
  • Demopoulos LA1
  • DiBattiste PM1
  • Frey MJ1
  • Gibson CM1
  • Lakkis N1
Leading institutions
free-text, unnormalised
  • Brigham and Women's Hospital1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Aspirin

Studied across 2 of the same disease areas as Tirofiban in the shared literature.

2 shared diseases1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials