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Drug

Uric Acid

In clinical development
Emerging researchLate-stage developmentRising momentum
Also known as Lithic acid, Uricum Acidum, 2,6,8-trihydroxypurine, 2,6,8-trioxopurine+3 more

Lithic acid, Uricum Acidum, 2,6,8-trihydroxypurine, 2,6,8-trioxopurine, 2,6,8-trioxypurine, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, Purine-2,6,8(1H,3H,9H)-trione.

RxNorm1427088ChEMBLCHEMBL792UNII268B43MJ25
3
Research papers
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this drug.

The Role of Purine Metabolism and Uric Acid in Postnatal Neurologic Development.

Research2025-02-11Molecules (Basel, Switzerland)

Elucidating the role of gut microbiota dysbiosis in hyperuricemia and gout: Insights and therapeutic strategies.

Research2024-10-01World journal of gastroenterology

The dysregulation of immune cells induced by uric acid: mechanisms of inflammation associated with hyperuricemia and its complications.

Research2023-11-20Frontiers in immunology

The Relationship Between Uric Acid and Inflammatory Markers

Clinical trial2014-01-31Completed · ClinicalTrials.gov

Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset

Clinical trial2013-10-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Uric Acid
Aliases & brands
Lithic acidUricum Acidum2,6,8-trihydroxypurine2,6,8-trioxopurine2,6,8-trioxypurine7,9-dihydro-1H-purine-2,6,8(3H)-trionePurine-2,6,8(1H,3H,9H)-trione
RxNorm CUI
1427088
ChEMBL ID
CHEMBL792
UNII
268B43MJ25

Clinical trials

2 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
2
registered trials across all phases
LATEST COMPLETION 2014
1
Late-stage (III+)
2
Completed
PHASE DISTRIBUTIONn = 2
Phase 11Phase 2 / 31

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset

CompletedPH II/IIIAngel Chamorro, MDn=4212013

Recent completions

Trials that read out recently, adding to the completed evidence base.

The Relationship Between Uric Acid and Inflammatory Markers

CompletedPH INational Institute on Aging (NIA)n=972014

Randomized, Double Blind Study Assessing the Clinical Efficacy of Combined Treatment With Uric Acid and rtPA Administered Intravenously in Acute Ischemic Stroke Patients Within the First 4.5 Hours of Symptoms Onset

CompletedPH II/IIIAngel Chamorro, MDn=4212013

Research activity

3 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Publications over time
20232025
Major research themes8
Gout2Hyperuricemia2Uric Acid2Arthritis, Gouty1Dysbiosis1Gastrointestinal Microbiome1Prebiotics1Probiotics1
Journals, researchers & institutions
Top journals
  • Frontiers in immunology1
  • Molecules (Basel, Switzerland)1
  • World journal of gastroenterology1
Leading researchers
  • Baleja JD1
  • Chen X1
  • Deng Y1
  • Durairajan SSK1
  • Fu X1
  • Iyaswamy A1
  • Li C1
  • Li D1
Leading institutions
free-text, unnormalised
  • Center for Excellence in Post-Harvest Technologies1
  • Guizhou Provincial People's Hospital1
  • Karpagam Academy of Higher Education1
  • Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae1
  • Nephrology Institute of Guangdong Provincial Academy of Chinese Medical Sciences (NIGH-CM)1
  • School of Biomedical Sciences1

Related diseases

2 conditions

Regulator-approved indications and conditions co-mentioned with this drug across the research literature. Number shows shared papers.

Active research areas
Gout2Hyperuricemia2
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials