Drug

Venlafaxine

In clinical development

Emerging researchLate-stage development

Also known as Effexor, Venlafaxina, Venlafaxine Hydrochloride, Venlafaxinum.

RxNorm39786 ChEMBLCHEMBL637UNIIGRZ5RCB1QG

Research papers

Active clinical trials

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Effect of Venlafaxine Versus Dosulepin on Clinical Outcomes, Neuroinflammation and Cortisol Level in Pain Predominant Somatic Symptom Disorder: A Group-sequential Randomized Controlled Trial

Clinical trial2026-08-01Primary completion · ClinicalTrials.gov

Venlafaxine for the Prevention of Depression in Patients With Head and Neck Cancer

Clinical trial2026-08-01Withdrawn · ClinicalTrials.gov

A Randomized, Open-Label Study to Assess the Pain, Toxicity, and Quality of Life Effects of Adding Venlafaxine to the Pain Management Regimen for Patients Treated With Chemoradiation for Head and Neck Cancer

Clinical trial2026-04-16Results posted · ClinicalTrials.gov

A Randomised, Controlled Trial to Investigate the Effect of an Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

Clinical trial2026-01-22Results expected Q2 2028 · ClinicalTrials.gov

Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea

Clinical trial2025-10-22Completed · ClinicalTrials.gov

A Randomised, Controlled Trial to Investigate the Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.

Clinical trial2025-09-26Results expected Q2 2028 · ClinicalTrials.gov

A Pragmatic Trial of Pharmacotherapy Options Following Unsatisfactory Initial Treatment in OCD

Clinical trial2025-05-15Results expected Q2 2027 · ClinicalTrials.gov

The Use of Venlafaxine in Reducing Acute Post-Surgical Pain and Opioid Consumption in Primary Total Knee Replacement

Clinical trial2025-03-31Completed · ClinicalTrials.gov

A Randomized Intrapatient Cross-over Study to Assess the Efficacy of Oxybutynin Versus Venlafaxine in Reducing Hot Flashes in Women Using Endocrine Therapy After Breast Cancer.

Clinical trial2025-02-04Results expected Q1 2029 · ClinicalTrials.gov

Serotonin-Norepinephrine Reuptake Inhibitors for the Prevention and Treatment of Pain, Depression, and Anxiety in Patients With Head & Neck Cancer

Clinical trial2024-10-01Withdrawn · ClinicalTrials.gov

Randomized, 2-Way Crossover, Bioequivalence Study of Venlafaxine 25 mg Tablets and Effexor® 25 mg Tablets Administered as 1 x 25 mg Tablet in Healthy Subjects Under Fasting Conditions

Clinical trial2024-08-19Results posted · ClinicalTrials.gov

Neurophysiologic effects of repeated exposure to antidepressant medication: are brain functional changes during antidepressant administration influenced by learning processes?

Research2013-09-17Medical hypotheses

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name

Venlafaxine

Aliases & brands

EffexorVenlafaxinaVenlafaxine HydrochlorideVenlafaxinum

RxNorm CUI

39786

ChEMBL ID

CHEMBL637

UNII

GRZ5RCB1QG

Clinical trials

92 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme

CLINICALTRIALS.GOV · LIVE REGISTRY

registered trials across all phases

LATEST COMPLETION 2025

Active studies

Recruiting

Late-stage (III+)

Completed

Discontinued

PHASE DISTRIBUTIONn = 92

Phase 18Phase 1 / 23Phase 212Phase 2 / 35Phase 318Phase 436Phase N / A10

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Effect of Venlafaxine Versus Dosulepin on Clinical Outcomes, Neuroinflammation and Cortisol Level in Pain Predominant Somatic Symptom Disorder: A Group-sequential Randomized Controlled Trial

RecruitingPH IVAll India Institute of Medical Sciences, Bhubaneswarn=842026

Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea

CompletedPH IVChina Medical University Hospitaln=452025

The Use of Venlafaxine in Reducing Acute Post-Surgical Pain and Opioid Consumption in Primary Total Knee Replacement

CompletedPH IVUniversity of California, San Franciscon=1002025

Serotonin-Norepinephrine Reuptake Inhibitors for the Prevention and Treatment of Pain, Depression, and Anxiety in Patients With Head & Neck Cancer

WithdrawnPH IVUniversity of Alabama at Birmingham2024

The Role of Negr1 In Modulating Neuroplasticity in Major Depression (RONIN)

Unknown statusPH IVFondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinicon=302024

Recent completions

Trials that read out recently, adding to the completed evidence base.

Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea

CompletedPH IVChina Medical University Hospitaln=452025

The Use of Venlafaxine in Reducing Acute Post-Surgical Pain and Opioid Consumption in Primary Total Knee Replacement

CompletedPH IVUniversity of California, San Franciscon=1002025

Assessing the Efficacy of a Serotonin and Norepinephrine Reuptake Inhibitor for Improving Meniere's Disease Outcomes

CompletedPH II/IIIMedical University of South Carolinan=402023

A Comparative Study of the Efficacy of Venlafaxine and Naltrexone for Relapse Prevention in Patients With Opioid Use Disorder Attributed to Tramadol

CompletedPH IVZagazig Universityn=522022

Rescuing OSA Patients Unable to Tolerate CPAP Using Endotype-Targeted Combination Drug Therapy: a Randomized, Double-Blind, Placebo-Controlled Trial

CompletedPH IIUniversity of California, San Diegon=202022

CompletedPH IIRoswell Park Cancer Instituten=622021

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Neurophysiologic effects of repeated exposure to antidepressant medication: are brain functional changes during antidepressant administration influenced by learning processes?

Medical hypotheses · 2013 · 7 cites