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Drug

Xylitol

Established medicine
ResearchOngoing clinical research

Also known as D-Xylitol, Salivasure, XyliMelts.

RxNorm11377ChEMBLCHEMBL96783UNIIVCQ006KQ1E
1
Research papers
2
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Xylitol Linked to Increased Long-Term Cardiovascular Risk

Industry2026-09-08Medscape Medical News

Xylitol Use for Decolonization of C. Difficile in Patients With Inflammatory Bowel Disease

Clinical trial2026-02-25Results expected Q1 2032 · ClinicalTrials.gov

Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients With Inflammatory Bowel Disease

Clinical trial2025-12-16Results expected Q3 2030 · ClinicalTrials.gov

Metabolic Effects of Selected Conventional and Alternative Sweeteners: A Narrative Review.

Research2024-02-23Nutrients

Randomized Controlled Study of Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Hospitalized Patients With Exacerbation of Cystic Fibrosis

Clinical trial2021-06-25Results posted · ClinicalTrials.gov

Healthcare Associated Infection Reduction in Stem Cell Transplant Patients: a Randomized, Double-blind, Placebo-controlled Study Evaluating Twice Daily Xylitol Administration

Clinical trial2021-03-20Terminated · ClinicalTrials.gov

A Novel Approach in Reducing Dental Pain and Anxiety of Pediatric Patient During Local Anesthesia. A Clinical Experimental Study

Clinical trial2021-02-18Completed · ClinicalTrials.gov

Antimicrobial Efficacy of Xylitol, Probiotic and Chlorhexidine Mouth Rinses Among Children and Elderly Population at High Risk for Dental Caries - A Double Blind Randomized Controlled Trial

Clinical trial2020-07-22Results posted · ClinicalTrials.gov

Randomized Cross Over Study of Inhaled Hypertonic Xylitol Versus Hypertonic Saline in Stable Subjects With Cystic Fibrosis

Clinical trial2018-10-24Results posted · ClinicalTrials.gov

Randomized Controlled Trial of Xylitol Versus Saline Rinse For Chronic Sinusitis

Clinical trial2018-08-31Results posted · ClinicalTrials.gov

Xylitol Topical Irrigation for Treatment of Recalcitrant Chronic Sinusitis

Clinical trial2018-07-16Completed · ClinicalTrials.gov

Double Blinded, Placebo Controlled Trial on the Effect of GABA Supplementation in the Progression of Type 1 Diabetes in Children

Clinical trial2012-12-24Withdrawn · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Xylitol
Aliases & brands
D-XylitolSalivasureXyliMelts
RxNorm CUI
11377
ChEMBL ID
CHEMBL96783
UNII
VCQ006KQ1E

Clinical trials

11 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
11
registered trials across all phases
LATEST COMPLETION 2021
2
Active studies
2
Recruiting
5
Late-stage (III+)
7
Completed
2
Discontinued
PHASE DISTRIBUTIONn = 11
Early Phase 11Phase 11Phase 1 / 22Phase 22Phase 2 / 32Phase 41Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Impact of Maternal Xylitol Consumption on Mutans Sterptococci ,Plaque and Caries Levels in Children

CompletedPH IVKing Abdulaziz Universityn=602011

Xylitol Topical Irrigation for Treatment of Recalcitrant Chronic Sinusitis

CompletedPH II/IIIOchsner Health Systemn=12018

Antimicrobial Efficacy of Xylitol, Probiotic and Chlorhexidine Mouth Rinses Among Children and Elderly Population at High Risk for Dental Caries - A Double Blind Randomized Controlled Trial

CompletedPH II/IIIDr. Krupa NCn=602017

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Novel Approach in Reducing Dental Pain and Anxiety of Pediatric Patient During Local Anesthesia. A Clinical Experimental Study

CompletedN/ARiyadh Elm Universityn=312021

Xylitol Topical Irrigation for Treatment of Recalcitrant Chronic Sinusitis

CompletedPH II/IIIOchsner Health Systemn=12018

Randomized Controlled Study of Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Hospitalized Patients With Exacerbation of Cystic Fibrosis

CompletedPH I/IIJoseph Zabnern=632018

Antimicrobial Efficacy of Xylitol, Probiotic and Chlorhexidine Mouth Rinses Among Children and Elderly Population at High Risk for Dental Caries - A Double Blind Randomized Controlled Trial

CompletedPH II/IIIDr. Krupa NCn=602017

Randomized Cross Over Study of Inhaled Hypertonic Xylitol Versus Hypertonic Saline in Stable Subjects With Cystic Fibrosis

CompletedPH I/IIJoseph Zabnern=302015

Randomized Controlled Trial of Xylitol Versus Saline Rinse For Chronic Sinusitis

CompletedN/AUniversity of Iowan=532014

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes2
Diabetes Mellitus, Type 21Sweetening Agents1
Journals, researchers & institutions
Top journals
  • Nutrients1
Leading researchers
  • Beglinger C1
  • Bordier V1
  • Meyer-Gerspach AC1
  • Teysseire F1
  • Wölnerhanssen BK1
Leading institutions
free-text, unnormalised
  • University of Basel1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Erythritol

Studied across the same disease area as Xylitol in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials