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Drug

Xylitol

In clinical development
Emerging researchLate-stage development

Also known as D-Xylitol, Salivasure, XyliMelts.

RxNorm11377ChEMBLCHEMBL96783UNIIVCQ006KQ1E
1
Research papers
2
Active clinical trials
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Xylitol Use for Decolonization of C. Difficile in Patients With Inflammatory Bowel Disease

Clinical trial2026-02-25Results expected Q1 2032 · ClinicalTrials.gov

Pilot Trial of Xylitol for C. Difficile De-Colonization in Patients With Inflammatory Bowel Disease

Clinical trial2025-12-16Results expected Q3 2030 · ClinicalTrials.gov

Metabolic Effects of Selected Conventional and Alternative Sweeteners: A Narrative Review.

Research2024-02-23Nutrients

Randomized Controlled Study of Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Hospitalized Patients With Exacerbation of Cystic Fibrosis

Clinical trial2021-06-25Results posted · ClinicalTrials.gov

Healthcare Associated Infection Reduction in Stem Cell Transplant Patients: a Randomized, Double-blind, Placebo-controlled Study Evaluating Twice Daily Xylitol Administration

Clinical trial2021-03-20Terminated · ClinicalTrials.gov

A Novel Approach in Reducing Dental Pain and Anxiety of Pediatric Patient During Local Anesthesia. A Clinical Experimental Study

Clinical trial2021-02-18Completed · ClinicalTrials.gov

Antimicrobial Efficacy of Xylitol, Probiotic and Chlorhexidine Mouth Rinses Among Children and Elderly Population at High Risk for Dental Caries - A Double Blind Randomized Controlled Trial

Clinical trial2020-07-22Results posted · ClinicalTrials.gov

Randomized Cross Over Study of Inhaled Hypertonic Xylitol Versus Hypertonic Saline in Stable Subjects With Cystic Fibrosis

Clinical trial2018-10-24Results posted · ClinicalTrials.gov

Randomized Controlled Trial of Xylitol Versus Saline Rinse For Chronic Sinusitis

Clinical trial2018-08-31Results posted · ClinicalTrials.gov

Xylitol Topical Irrigation for Treatment of Recalcitrant Chronic Sinusitis

Clinical trial2018-07-16Completed · ClinicalTrials.gov

Double Blinded, Placebo Controlled Trial on the Effect of GABA Supplementation in the Progression of Type 1 Diabetes in Children

Clinical trial2012-12-24Withdrawn · ClinicalTrials.gov

Impact of Maternal Xylitol Consumption on Mutans Sterptococci ,Plaque and Caries Levels in Children

Clinical trial2011-09-01Completed · ClinicalTrials.gov

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Xylitol
Aliases & brands
D-XylitolSalivasureXyliMelts
RxNorm CUI
11377
ChEMBL ID
CHEMBL96783
UNII
VCQ006KQ1E

Clinical trials

11 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
11
registered trials across all phases
LATEST COMPLETION 2021
2
Active studies
2
Recruiting
5
Late-stage (III+)
7
Completed
2
Discontinued
PHASE DISTRIBUTIONn = 11
Early Phase 11Phase 11Phase 1 / 22Phase 22Phase 2 / 32Phase 41Phase N / A2

Late-stage studies

Phase III+ trials still open or recently active — where late-stage evidence is being generated.

Impact of Maternal Xylitol Consumption on Mutans Sterptococci ,Plaque and Caries Levels in Children

CompletedPH IVKing Abdulaziz Universityn=602011

Xylitol Topical Irrigation for Treatment of Recalcitrant Chronic Sinusitis

CompletedPH II/IIIOchsner Health Systemn=12018

Antimicrobial Efficacy of Xylitol, Probiotic and Chlorhexidine Mouth Rinses Among Children and Elderly Population at High Risk for Dental Caries - A Double Blind Randomized Controlled Trial

CompletedPH II/IIIDr. Krupa NCn=602017

Recent completions

Trials that read out recently, adding to the completed evidence base.

A Novel Approach in Reducing Dental Pain and Anxiety of Pediatric Patient During Local Anesthesia. A Clinical Experimental Study

CompletedN/ARiyadh Elm Universityn=312021

Xylitol Topical Irrigation for Treatment of Recalcitrant Chronic Sinusitis

CompletedPH II/IIIOchsner Health Systemn=12018

Randomized Controlled Study of Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Hospitalized Patients With Exacerbation of Cystic Fibrosis

CompletedPH I/IIJoseph Zabnern=632018

Antimicrobial Efficacy of Xylitol, Probiotic and Chlorhexidine Mouth Rinses Among Children and Elderly Population at High Risk for Dental Caries - A Double Blind Randomized Controlled Trial

CompletedPH II/IIIDr. Krupa NCn=602017

Randomized Cross Over Study of Inhaled Hypertonic Xylitol Versus Hypertonic Saline in Stable Subjects With Cystic Fibrosis

CompletedPH I/IIJoseph Zabnern=302015

Randomized Controlled Trial of Xylitol Versus Saline Rinse For Chronic Sinusitis

CompletedN/AUniversity of Iowan=532014

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Major research themes2
Diabetes Mellitus, Type 21Sweetening Agents1
Journals, researchers & institutions
Top journals
  • Nutrients1
Leading researchers
  • Beglinger C1
  • Bordier V1
  • Meyer-Gerspach AC1
  • Teysseire F1
  • Wölnerhanssen BK1
Leading institutions
free-text, unnormalised
  • University of Basel1

Related drugs

1 matches

Drugs sharing diseases, protein targets and literature with this one. Ranked by graph evidence (shared targets + diseases weighted above co-mentions).

Erythritol

Studied across the same disease area as Xylitol in the shared literature.

1 shared disease1 shared paper
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials