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Drug

Zenocutuzumab

In clinical development
ClassErbB-2/ErbB-3 heterodimer inhibitorEmerging researchEarly-to-mid development

Also known as Bizengri, Mcla-128 (igg1 bispecific antibody with enhanced antibody-dependent cell-mediated cytotoxicity (adcc) activity targeting her2 and her3 receptors.), Immunoglobulin g1, bispecific, anti-(human epidermal growth factor receptors, her2 and her3) (humanized clone mcla-128 .gamma.1-chain), disulfide with humanized clone mcla-128 light chain, dimer.

1
Research papers
1
Active clinical trials
2
Protein targets
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this drug.

Profile

Identifiers & mechanism

Canonical identifiers, marketed brand names and mechanism, resolved across RxNorm, ChEMBL and ATC.

Canonical name
Zenocutuzumab
Aliases & brands
BizengriMcla-128 (igg1 bispecific antibody with enhanced antibody-dependent cell-mediated cytotoxicity (adcc) activity targeting her2 and her3 receptors.)Immunoglobulin g1, bispecific, anti-(human epidermal growth factor receptors, her2 and her3) (humanized clone mcla-128 .gamma.1-chain), disulfide with humanized clone mcla-128 light chain, dimer
RxNorm CUI
2699588
ChEMBL ID
CHEMBL4298025
UNII
AE72RB1W1X
Primary mechanism
ErbB-2/ErbB-3 heterodimer inhibitor

Pharmacology & targets

2 targets

Known molecular targets and mechanisms supported by curated pharmacology databases.

INHIBITORErbB-2/ErbB-3 heterodimer inhibitor
INHIBITORErbB-2/ErbB-3 heterodimer inhibitor

Clinical trials

2 trials

The current development programme across all trial phases — status mix, phase distribution and the late-stage studies shaping the evidence base.

Development programme
CLINICALTRIALS.GOV · LIVE REGISTRY
2
registered trials across all phases
LATEST COMPLETION 2023
1
Active studies
1
Completed
PHASE DISTRIBUTIONn = 2
Phase 22

Research activity

1 papers

Key research shaping understanding of this drug, combining the latest publications with the most influential evidence.

Most influential

Efficacy of Zenocutuzumab in <i>NRG1</i> Fusion-Positive Cancer.

The New England journal of medicine · 2025 · 78 cites
Recent papers

Efficacy of Zenocutuzumab in <i>NRG1</i> Fusion-Positive Cancer.

The New England journal of medicine · 2025 · 78 cites
Major research themes5
Antibodies, Bispecific1Antineoplastic Agents, Immunological1Neoplasms1Neuregulin-11Oncogene Proteins, Fusion1
Journals, researchers & institutions
Top journals
  • The New England journal of medicine1
Leading researchers
  • Adeyemi S1
  • Bekaii-Saab T1
  • Calvo E1
  • Cleary JM1
  • Drilon A1
  • Duruisseaux M1
  • Ford J1
  • Goto K1
Leading institutions
free-text, unnormalised
  • Abramson Cancer Center1
  • Chao Family Comprehensive Cancer Center1
  • Curie Institute1
  • Dana-Farber Cancer Institute1
  • Harvard Medical School1
  • Lombardi Comprehensive Cancer Center1
References & data sources
  • RxNorm (U.S. National Library of Medicine) — drug identity
  • ChEMBL (EMBL-EBI) & UniProt — pharmacology and targets
  • Europe PMC — research literature
  • ClinicalTrials.gov — clinical trials