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AARS1

Gene

alanyl-tRNA synthetase 1

HGNCHGNC:20EnsemblENSG00000090861NCBI Gene16
Locus: gene with protein productLocation: 16q22.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAARS · CMT2N · AlaRS
View full nomenclature history (5)
Previous symbolsAARS
Alias symbolsCMT2N, AlaRS
Previous namesalanyl-tRNA synthetase
Alias namesalanine tRNA ligase 1, cytoplasmic

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Undetermined early-onset epileptic encephalopathy
Genetic Diseases, Inborn
Charcot-Marie-Tooth Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Aminoacyl tRNA synthetases, Class II

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.