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ABCC8

Gene

ATP binding cassette subfamily C member 8

HGNCHGNC:59EnsemblENSG00000006071NCBI Gene6833
Locus: gene with protein productLocation: 11p15.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

ATP-binding cassette sub-family C member 8Q09428

Protein · therapeutic target

Clinically validated target · 12 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSUR · HRINS · HI · PHHI · SUR1 · MRP8 · ABC36 · HHF1 · TNDM2
View full nomenclature history (11)
Previous symbolsSUR, HRINS
Alias symbolsHI, PHHI, SUR1, MRP8, ABC36, HHF1, TNDM2
Previous namesATP-binding cassette, sub-family C (CFTR/MRP), member 8
Alias namessulfonylurea receptor (hyperinsulinemia)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetes Mellitus, Type 2
Hyperinsulinemic hypoglycemia, familial, 1
Diabetes mellitus, permanent neonatal 3
Diabetes mellitus, transient neonatal, 2
Diabetes Mellitus
Leucine-induced hypoglycemia
Permanent neonatal diabetes mellitus
Transient neonatal diabetes mellitus
autosomal dominant hyperinsulinism due to SUR1 deficiency

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ATP binding cassette subfamily C

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.