ACVR2B

Gene

activin A receptor type 2B

HGNCHGNC:174 EnsemblENSG00000114739 NCBI Gene93

Locus: gene with protein productLocation: 3p22.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Activin receptor type-2BQ13705

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asActR-IIB

View full nomenclature history (2)

Alias symbolsActR-IIB

Previous namesactivin A receptor, type IIB

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Heterotaxia

Visceral heterotaxy

Bone Diseases

Inclusion body myositis

Autoimmune disorder of central nervous system

Neurodegenerative Diseases

Disorder of pilosebaceous unit

Multiple Sclerosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Type 2 receptor serine/threonine kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.