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AFG3L2

Gene

AFG3 like matrix AAA peptidase subunit 2

HGNCHGNC:315EnsemblENSG00000141385NCBI Gene10939
Locus: gene with protein productLocation: 18p11.21

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSCA28 · SPAX5
View full nomenclature history (6)
Previous symbolsSCA28
Alias symbolsSPAX5
Previous namesAFG3 (ATPase family gene 3, yeast)-like 2, spinocerebellar ataxia 28, AFG3 ATPase family member 3-like 2 (S. cerevisiae), AFG3 like AAA ATPase 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Optic Atrophy
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

AAA ATPases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.