AKR1B1

Gene

aldo-keto reductase family 1 member B

HGNCHGNC:381 EnsemblENSG00000085662 NCBI Gene231

Locus: gene with protein productLocation: 7q33

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asALDR1 · AR

View full nomenclature history (4)

Previous symbolsALDR1

Alias symbolsAR

Previous namesaldo-keto reductase family 1, member B1 (aldose reductase)

Alias namesaldose reductase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Diabetic Neuropathies

Diabetes Mellitus

Neurodegenerative Diseases

Hypertension

Essential Hypertension

Carcinoma, Hepatocellular

Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Aldo-keto reductases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.