AKR1C3

Gene

aldo-keto reductase family 1 member C3

HGNCHGNC:386 EnsemblENSG00000196139 NCBI Gene8644

Locus: gene with protein productLocation: 10p15.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Aldo-keto reductase family 1 member C3P42330

Protein · therapeutic target

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Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHSD17B5 · KIAA0119 · DDX · HAKRB · PGFS

View full nomenclature history (10)

Previous symbolsHSD17B5

Alias symbolsKIAA0119, DDX, HAKRB, PGFS

Previous nameshydroxysteroid (17-beta) dehydrogenase 5, aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

Alias namesdihydrodiol dehydrogenase X, prostaglandin F synthase, 3-alpha hydroxysteroid dehydrogenase, type II

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Familial prostate cancer

Prostatic Neoplasms

Carcinoma, Hepatocellular

Neoplasms

Stomach Neoplasms

Liver Neoplasms

Small Cell Lung Carcinoma

Polycystic Ovary Syndrome

Prostate carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Aldo-keto reductases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.