AKT1

Gene

AKT serine/threonine kinase 1

HGNCHGNC:391 EnsemblENSG00000142208 NCBI Gene207

Locus: gene with protein productLocation: 14q32.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

RAC-alpha serine/threonine-protein kinaseP31749

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRAC · PKB · PRKBA · AKT · RAC-alpha

View full nomenclature history (7)

Alias symbolsRAC, PKB, PRKBA, AKT, RAC-alpha

Previous namesv-akt murine thymoma viral oncogene homolog 1

Alias namesprotein kinase B

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Breast adenocarcinoma

Colorectal adenocarcinoma

Ovarian carcinoma

Meningioma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingAKT kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.