Back to discover

ALDH5A1

Gene

aldehyde dehydrogenase 5 family member A1

HGNCHGNC:408EnsemblENSG00000112294NCBI Gene7915
Locus: gene with protein productLocation: 6p22.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Succinate-semialdehyde dehydrogenase, mitochondrialP51649

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSSDH · SSADH
View full nomenclature history (4)
Alias symbolsSSDH, SSADH
Previous namesaldehyde dehydrogenase 5 family, member A1
Alias namessuccinate-semialdehyde dehydrogenase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Succinic semialdehyde dehydrogenase deficiency
Epilepsy
Bipolar Disorder
Major depressive disorder
Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Aldehyde dehydrogenases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.