APC

Gene

APC regulator of Wnt signaling pathway

HGNCHGNC:583 EnsemblENSG00000134982 NCBI Gene324

Locus: gene with protein productLocation: 5q22.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Adenomatous polyposis coli proteinP25054

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDP2 · DP3 · DP2.5 · PPP1R46

View full nomenclature history (9)

Alias symbolsDP2, DP3, DP2.5, PPP1R46

Previous namesAPC regulator of WNT signaling pathway, adenomatosis polyposis coli, adenomatous polyposis coli, APC, WNT signaling pathway regulator

Alias namesprotein phosphatase 1, regulatory subunit 46

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Adenomatous Polyposis Coli

Colon carcinoma

Colorectal adenocarcinoma

Colorectal Neoplasms

Colonic Neoplasms

Carcinoma, Hepatocellular

Desmoid Tumors

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Armadillo repeat containingProtein phosphatase 1 regulatory subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-06-27.

Open TargetsGene–disease associations from the Open Targets Platform.