APH1B

Gene

aph-1B gamma-secretase subunit

HGNCHGNC:24080 EnsemblENSG00000138613 NCBI Gene83464

Locus: gene with protein productLocation: 15q22.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPSFL · APH-1B · DKFZp564D0372

View full nomenclature history (7)

Alias symbolsPSFL, APH-1B, DKFZp564D0372

Previous namesaph-1 homolog B, gamma-secretase subunit, aph-1B gamma-secretase subunit, anterior pharynx defective 1 homolog B (C. elegans), APH1B gamma secretase subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

late-onset Alzheimers disease

Parkinson's Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Gamma-secretase complex subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-09-17.

Open TargetsGene–disease associations from the Open Targets Platform.