APLNR

Gene

apelin receptor

HGNCHGNC:339 EnsemblENSG00000134817 NCBI Gene187

Locus: gene with protein productLocation: 11q12.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Apelin receptorP35414

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAGTRL1 · FLJ90771 · APJ · APJR

View full nomenclature history (6)

Previous symbolsAGTRL1

Alias symbolsFLJ90771, APJ, APJR

Previous namesangiotensin II receptor-like 1

Alias namesAPJ (apelin) receptor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Essential Hypertension

Hypertension

Neoplasms

Pulmonary arterial hypertension

Diabetes Mellitus, Type 2

Glioblastoma

Non-alcoholic Fatty Liver Disease

Coronary Artery Disease

Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Apelin receptor

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.