ARAF

Gene

A-Raf proto-oncogene, serine/threonine kinase

HGNCHGNC:646 EnsemblENSG00000078061 NCBI Gene369

Locus: gene with protein productLocation: Xp11.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Serine/threonine-protein kinase A-RafP10398

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asARAF1 · A-Raf

View full nomenclature history (3)

Previous symbolsARAF1

Alias symbolsA-Raf

Previous namesv-raf murine sarcoma 3611 viral oncogene homolog 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms

Noonan syndrome

Cardiomyopathy, Hypertrophic

Costello syndrome

Glioma

Colorectal adenocarcinoma

Adenocarcinoma of Lung

Small Cell Lung Carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Mitogen-activated protein kinase kinase kinasesRAF family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-07-12.

Open TargetsGene–disease associations from the Open Targets Platform.