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AREG

Gene

amphiregulin

HGNCHGNC:651EnsemblENSG00000109321NCBI Gene374
Locus: gene with protein productLocation: 4q13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

AmphiregulinP15514

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSDGF · AREGB · AR · CRDGF
View full nomenclature history (7)
Previous symbolsSDGF, AREGB
Alias symbolsAR, CRDGF
Previous namesschwannoma-derived growth factor, amphiregulin B
Alias namesColorectum Cell-Derived Growth Factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms
Neurodegenerative Diseases
Colorectal adenocarcinoma
Hair color
Rheumatic Heart Disease
Breast Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Receptor ligands

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-07-12.
Open TargetsGene–disease associations from the Open Targets Platform.