ARHGEF6

Gene

Rac/Cdc42 guanine nucleotide exchange factor 6

HGNCHGNC:685 EnsemblENSG00000129675 NCBI Gene9459

Locus: gene with protein productLocation: Xq26.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMRX46 · alphaPIX · Cool-2 · KIAA0006 · alpha-PIX · Cool2 · αPix

View full nomenclature history (12)

Previous symbolsMRX46

Alias symbolsalphaPIX, Cool-2, KIAA0006, alpha-PIX, Cool2, αPix

Previous namesmental retardation, X-linked 46, Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

Alias namesRac/Cdc42 guanine exchange factor (GEF) 6, PAK-interacting exchange factor, alpha, rho guanine nucleotide exchange factor 6

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Sleep Initiation and Maintenance Disorders

Coronary Artery Disease

Leukoencephalopathies

Leukemia, Myeloid, Acute

Neoplasms

Hyperkalemic periodic paralysis

Diabetes Mellitus, Type 2

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingDbl family Rho GEFs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.