ATP1A3

Gene

ATPase Na+/K+ transporting subunit alpha 3

HGNCHGNC:801 EnsemblENSG00000105409 NCBI Gene478

Locus: gene with protein productLocation: 19q13.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium/potassium-transporting ATPase subunit alpha-3P13637

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDYT12

View full nomenclature history (6)

Previous symbolsDYT12

Previous namesdystonia 12, ATPase, Na+/K+ transporting, alpha 3 polypeptide

Alias namessodium/potassium-transporting ATPase subunit alpha-3, sodium pump subunit alpha-3, sodium-potassium ATPase catalytic subunit alpha-3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Alternating hemiplegia of childhood 2

Dystonia 12

Cerebellar ataxia - areflexia - pes cavus - optic atrophy - sensorineural hearing loss

Developmental and epileptic encephalopathy 99

Cerebellar ataxia-areflexia-pes cavus-optic atrophy-sensorineural hearing loss syndrome

Alternating hemiplegia of childhood

Rapid-onset dystonia-parkinsonism

ATP1A3-associated neurological disorder

Heart Failure

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ATPase Na+/K+ transporting subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-09-13.

Open TargetsGene–disease associations from the Open Targets Platform.