ATP1A4

Gene

ATPase Na+/K+ transporting subunit alpha 4

HGNCHGNC:14073 EnsemblENSG00000132681 NCBI Gene480

Locus: gene with protein productLocation: 1q23.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium/potassium-transporting ATPase subunit alpha-4Q13733

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asATP1AL2

View full nomenclature history (6)

Previous symbolsATP1AL2

Previous namesATPase, Na+/K+ transporting, alpha polypeptide-like 2, ATPase, Na+/K+ transporting, alpha 4 polypeptide

Alias namessodium/potassium-transporting ATPase subunit alpha-4, sodium pump subunit alpha-4, sodium-potassium ATPase catalytic subunit alpha-4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Non-syndromic male infertility due to sperm motility disorder

Spermatogenic failure

Breast Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ATPase Na+/K+ transporting subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.