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ATP2B4

Gene

ATPase plasma membrane Ca2+ transporting 4

HGNCHGNC:817EnsemblENSG00000058668NCBI Gene493
Locus: gene with protein productLocation: 1q32.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asATP2B2 · MXRA1 · PMCA4
View full nomenclature history (6)
Previous symbolsATP2B2, MXRA1
Alias symbolsPMCA4
Previous namesmatrix-remodelling associated 1, ATPase, Ca++ transporting, plasma membrane 4
Alias namesplasma membrane calcium-transporting ATPase 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Malaria
Chronic venous hypertension
Infertility, Male
Familial prostate cancer
Prostatic Neoplasms
Melanoma
Non-syndromic male infertility due to sperm motility disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

ATPases Ca2+ transportingSmall nucleolar RNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-10-11.
Open TargetsGene–disease associations from the Open Targets Platform.