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BCR

Gene

BCR activator of RhoGEF and GTPase

HGNCHGNC:1014EnsemblENSG00000186716NCBI Gene613
Locus: gene with protein productLocation: 22q11.23

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Breakpoint cluster region proteinP11274

Protein · therapeutic target

Clinically validated target · 12 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asD22S11 · BCR1 · D22S662 · CML · PHL · ALL
View full nomenclature history (8)
Previous symbolsD22S11, BCR1
Alias symbolsD22S662, CML, PHL, ALL
Previous namesbreakpoint cluster region, BCR, RhoGEF and GTPase activating protein

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

chronic myelogenous leukemia, BCR-ABL1 positive
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neoplasms
blast phase chronic myelogenous leukemia, BCR-ABL1 positive
Gastrointestinal Stromal Tumors
Dermatofibrosarcoma protuberans
Hypereosinophilic syndrome
Myelodysplastic syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Pleckstrin homology domain containingDbl family Rho GEFsC2 domain containingMy-T-BRC complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.