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BHLHE22

Gene

basic helix-loop-helix family member e22

HGNCHGNC:11963EnsemblENSG00000180828NCBI Gene27319
Locus: gene with protein productLocation: 8q12.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asBHLHB5 · TNRC20 · CAGL85 · Beta3
View full nomenclature history (7)
Previous symbolsBHLHB5, TNRC20
Alias symbolsCAGL85, Beta3
Previous namestrinucleotide repeat containing 20, basic helix-loop-helix domain containing, class B, 5, basic helix-loop-helix family, member e22

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Risk-taking behaviour
Neurodegenerative Diseases
Attention Deficit Disorder with Hyperactivity
Schizophrenia
Smoking initiation
Major depressive disorder
Diabetes Mellitus, Type 2

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Basic helix-loop-helix proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.