BRCA2

Gene

BRCA2 DNA repair associated

HGNCHGNC:1101 EnsemblENSG00000139618 NCBI Gene675

Locus: gene with protein productLocation: 13q13.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Breast cancer type 2 susceptibility proteinP51587

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFANCD1 · FACD · FANCD · FAD · FAD1 · BRCC2 · XRCC11

View full nomenclature history (11)

Previous symbolsFANCD1, FACD, FANCD

Alias symbolsFAD, FAD1, BRCC2, XRCC11

Previous namesFanconi anemia, complementation group D1, breast cancer 2, early onset, breast cancer 2

Alias namesBRCA1/BRCA2-containing complex, subunit 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms

Breast Neoplasms

Ovarian Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

FA complementation groups

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.