BRIP1

Gene

BRCA1 interacting DNA helicase 1

HGNCHGNC:20473 EnsemblENSG00000136492 NCBI Gene83990

Locus: gene with protein productLocation: 17q23.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asOF · BACH1 · FANCJ

View full nomenclature history (9)

Alias symbolsOF, BACH1, FANCJ

Previous namesBRCA1 interacting helicase 1, BRCA1 interacting protein C-terminal helicase 1

Alias namesBRCA1/BRCA2-associated helicase 1, FANCJ helicase, BRCA1-associated C-terminal helicase, BRCA1 interacting protein 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Fanconi Anemia

Breast Neoplasms

Ovarian Neoplasms

Inherited cancer-predisposing syndrome

Neoplastic Syndromes, Hereditary

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DEAH-box helicasesFA complementation groupsBRCA1 B complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-09-05.

Open TargetsGene–disease associations from the Open Targets Platform.