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CACNA1E

Gene

calcium voltage-gated channel subunit alpha1 E

HGNCHGNC:1392EnsemblENSG00000198216NCBI Gene777
Locus: gene with protein productLocation: 1q25.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Voltage-dependent R-type calcium channel subunit alpha-1EQ15878

Protein · therapeutic target

Clinically validated target · 7 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCACNL1A6 · Cav2.3 · BII · CACH6
View full nomenclature history (6)
Previous symbolsCACNL1A6
Alias symbolsCav2.3, BII, CACH6
Previous namescalcium channel, voltage-dependent, R type, alpha 1E subunit, calcium voltage-gated channel subunit alpha1 subunit E

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic developmental and epileptic encephalopathy
Epilepsy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

EF-hand domain containingCalcium voltage-gated channel alpha1 subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.