Back to discover

CACNA1S

Gene

calcium voltage-gated channel subunit alpha1 S

HGNCHGNC:1397EnsemblENSG00000081248NCBI Gene779
Locus: gene with protein productLocation: 1q32.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Voltage-dependent L-type calcium channel subunit alpha-1SQ13698

Protein · therapeutic target

Clinically validated target · 36 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asHOKPP · MHS5 · CACNL1A3 · Cav1.1 · hypoPP
View full nomenclature history (6)
Previous symbolsHOKPP, MHS5, CACNL1A3
Alias symbolsCav1.1, hypoPP
Previous namescalcium channel, voltage-dependent, L type, alpha 1S subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hypokalemic periodic paralysis, type 1
Congenital myopathy 18
Malignant hyperthermia of anesthesia
Hypertension
Epilepsy

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Calcium voltage-gated channel alpha1 subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.