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CALR

Gene

calreticulin

HGNCHGNC:1455EnsemblENSG00000179218NCBI Gene811
Locus: gene with protein productLocation: 19p13.13

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

CalreticulinP27797

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRO · SSA · cC1qR · CRT · FLJ26680 · CALR1
View full nomenclature history (9)
Alias symbolsRO, SSA, cC1qR, CRT, FLJ26680, CALR1
Alias namesSicca syndrome antigen A (autoantigen Ro; calreticulin), autoantigen Ro, calregulin

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms
Myeloproliferative disorder
Primary myelofibrosis
Hemorrhagic disease
Neurodegenerative Diseases
Alzheimer's Disease
Parkinson's Disease
Multiple Sclerosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-05-24.
Open TargetsGene–disease associations from the Open Targets Platform.