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CASK

Gene

calcium/calmodulin dependent serine protein kinase

HGNCHGNC:1497EnsemblENSG00000147044NCBI Gene8573
Locus: gene with protein productLocation: Xp11.4

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asTNRC8 · LIN2 · CAGH39 · FGS4
View full nomenclature history (6)
Previous symbolsTNRC8
Alias symbolsLIN2, CAGH39, FGS4
Previous namestrinucleotide repeat containing 8, calcium/calmodulin-dependent serine protein kinase (MAGUK family)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Developmental Disabilities

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Membrane associated guanylate kinasesPDZ domain containingCASK family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.