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CASP2

Gene

caspase 2

HGNCHGNC:1503EnsemblENSG00000106144NCBI Gene835
Locus: gene with protein productLocation: 7q34

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asNEDD2 · MGC2181 · ICH1 · PPP1R57
View full nomenclature history (7)
Previous symbolsNEDD2
Alias symbolsMGC2181, ICH1, PPP1R57
Previous namesneural precursor cell expressed, developmentally down-regulated 2, caspase 2, apoptosis-related cysteine peptidase
Alias namesprotein phosphatase 1, regulatory subunit 57

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Neoplasms
Leukemia, Myeloid, Acute
Huntington's Disease
Neuroblastoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CaspasesProtein phosphatase 1 regulatory subunitsCaspase recruitment domain containingCaspase-2 PIDDosome complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.