CASP8

Gene

caspase 8

HGNCHGNC:1509 EnsemblENSG00000064012 NCBI Gene841

Locus: gene with protein productLocation: 2q33.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMCH5 · MACH · FLICE · Casp-8

View full nomenclature history (6)

Alias symbolsMCH5, MACH, FLICE, Casp-8

Previous namescaspase 8, apoptosis-related cysteine protease, caspase 8, apoptosis-related cysteine peptidase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Squamous Cell Carcinoma of Head and Neck

Neurodegenerative Diseases

Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CaspasesDeath effector domain containingRipoptosomeDeath inducing signaling complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.