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CD3D

Gene

CD3 delta subunit of T-cell receptor complex

HGNCHGNC:1673EnsemblENSG00000167286NCBI Gene915
Locus: gene with protein productLocation: 11q23.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

T-cell surface glycoprotein CD3 delta chainP04234

Protein · therapeutic target

Clinically validated target · 11 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asT3D · CD3DELTA · CD3-DELTA
View full nomenclature history (7)
Previous symbolsT3D
Alias symbolsCD3DELTA, CD3-DELTA
Previous namesCD3d antigen, delta polypeptide (TiT3 complex), CD3d molecule, delta (CD3-TCR complex), CD3d molecule
Alias namesT-cell surface glycoprotein CD3 delta chain

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Immunodeficiency 19
Multiple Myeloma
Neoplasms
Lymphoma, Large B-Cell, Diffuse
Precursor Cell Lymphoblastic Leukemia-Lymphoma
T-B- severe combined immunodeficiency

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD molecules

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.