CD3E

Gene

CD3 epsilon subunit of T-cell receptor complex

HGNCHGNC:1674 EnsemblENSG00000198851 NCBI Gene916

Locus: gene with protein productLocation: 11q23.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

T-cell surface glycoprotein CD3 epsilon chainP07766

Protein · therapeutic target

Clinically validated target · 12 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCD3epsilon · CD3-epsilon

View full nomenclature history (6)

Alias symbolsCD3epsilon, CD3-epsilon

Previous namesCD3e antigen, epsilon polypeptide (TiT3 complex), CD3e molecule, epsilon (CD3-TCR complex), CD3e molecule

Alias namesT-cell surface glycoprotein CD3 epsilon chain

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lymphoma, Large B-Cell, Diffuse

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Diabetes Mellitus, Type 1

Small Cell Lung Carcinoma

B-cell acute lymphoblastic leukemia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD molecules

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.