CD46

Gene

CD46 molecule

HGNCHGNC:6953 EnsemblENSG00000117335 NCBI Gene4179

Locus: gene with protein productLocation: 1q32.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMIC10 · MCP · TRA2.10 · MGC26544 · TLX

View full nomenclature history (10)

Previous symbolsMIC10, MCP

Alias symbolsTRA2.10, MGC26544, TLX

Previous namesantigen identified by monoclonal antibody TRA-2-10, CD46 antigen, complement regulatory protein, CD46 molecule, complement regulatory protein, membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen)

Alias namestrophoblast-lymphocyte cross-reactive antigen

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Thrombotic Microangiopathies

Macular Degeneration

Retinal Diseases

Cartilage Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesSushi domain containingComplement system regulators and receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.