CDKN2A

Gene

cyclin dependent kinase inhibitor 2A

HGNCHGNC:1787 EnsemblENSG00000147889 NCBI Gene1029

Locus: gene with protein productLocation: 9p21.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCDKN2 · MLM · CDK4I · p16 · INK4a · MTS1 · CMM2 · ARF · p19 · p14 · INK4 · p16INK4a · p19Arf · p14ARF · P16-INK4A · CAI2

View full nomenclature history (23)

Previous symbolsCDKN2, MLM

Alias symbolsCDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4, p16INK4a, p19Arf, p14ARF, P16-INK4A, CAI2

Previous namescyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Alias namesCDKN2A/ARF Intron 2 lncRNA, multiple tumour suppressor 1, cyclin-dependent kinase 4 inhibitor A, p19 alternate open reading frame, p14 alternate open reading frame, inhibitor of cdk4 A

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Melanoma

Cutaneous melanoma

Familial melanoma

Squamous cell lung carcinoma

Squamous Cell Carcinoma of Head and Neck

Neoplasms

Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cyclin dependent kinase inhibitor 2 family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-08-25.

Open TargetsGene–disease associations from the Open Targets Platform.