CFTR

Gene

CF transmembrane conductance regulator

HGNCHGNC:1884 EnsemblENSG00000001626 NCBI Gene1080

Locus: gene with protein productLocation: 7q31.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Cystic fibrosis transmembrane conductance regulatorP13569

Protein · therapeutic target

Clinically validated target · 7 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCF · ABCC7 · MRP7 · ABC35 · TNR-CFTR · dJ760C5.1 · CFTR/MRP

View full nomenclature history (9)

Previous symbolsCF, ABCC7

Alias symbolsMRP7, ABC35, TNR-CFTR, dJ760C5.1, CFTR/MRP

Previous namescystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)

Alias namesATP-binding cassette sub-family C, member 7

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cystic Fibrosis

congenital bilateral aplasia of vas deferens from CFTR mutation

Hereditary chronic pancreatitis

Bronchiectasis with or without elevated sweat chloride 1

Congenital bilateral absence of vas deferens

Bronchiectasis

Acute Lung Injury

Cholestasis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Chloride channels, ATP-gated CFTRATP binding cassette subfamily C

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-10-02.

Open TargetsGene–disease associations from the Open Targets Platform.